Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

Han Lin Chiang, Guey-Jen Lee, Chiung Mei Chen, Yi Chun Chen, Chei Mei Lee, Ming Hui Liao, Yih Ru Wu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.

Original languageEnglish
Pages (from-to)391-393
Number of pages3
JournalParkinsonism and Related Disorders
Volume18
Issue number4
DOIs
Publication statusPublished - 2012 May 1

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HLA-DR alpha-Chains
Parkinson Disease
Metagenomics
Genome-Wide Association Study
Neurodegenerative Diseases
Population
Single Nucleotide Polymorphism

Keywords

  • Disease association
  • HLA
  • Parkinson's disease
  • Polymorphism

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease. / Chiang, Han Lin; Lee, Guey-Jen; Chen, Chiung Mei; Chen, Yi Chun; Lee, Chei Mei; Liao, Ming Hui; Wu, Yih Ru.

In: Parkinsonism and Related Disorders, Vol. 18, No. 4, 01.05.2012, p. 391-393.

Research output: Contribution to journalArticle

Chiang, Han Lin ; Lee, Guey-Jen ; Chen, Chiung Mei ; Chen, Yi Chun ; Lee, Chei Mei ; Liao, Ming Hui ; Wu, Yih Ru. / Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease. In: Parkinsonism and Related Disorders. 2012 ; Vol. 18, No. 4. pp. 391-393.
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