Genetic analysis of HLA-DRA region variation in Taiwanese Parkinson's disease

Han Lin Chiang, Guey Jen Lee-Chen, Chiung Mei Chen, Yi Chun Chen, Chei Mei Lee, Ming Hui Liao, Yih Ru Wu

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Parkinson's disease (PD) is a neurodegenerative disorder comprising both motor and cognitive disability. The pathogenesis of the disease is still unclear; however, neuroinflammation seemed to play a role. A recent genome-wide association study (GWAS) reported an association between HLA-DRA rs3129882 and the development of PD in Caucasian populations. In this study, we observe no association between this single nucleotide polymorphism and PD in a Taiwanese population. The possible reasons include different ethnicity with genomic differences and environmental factors in different geographical regions.

Original languageEnglish
Pages (from-to)391-393
Number of pages3
JournalParkinsonism and Related Disorders
Volume18
Issue number4
DOIs
Publication statusPublished - 2012 May 1

Keywords

  • Disease association
  • HLA
  • Parkinson's disease
  • Polymorphism

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

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