GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus

Philip H.S. Jen; Chung Hsin Wu; Rui Hong Luan; Xiaoming Zhou

doi:10.1016/S0006-8993(02)03056-1

GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus

Philip H.S. Jen, Chung Hsin Wu, Rui Hong Luan, Xiaoming Zhou

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Q_n (Q₁₀, Q₂₀, Q₃₀) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.

Original language	English
Pages (from-to)	159-164
Number of pages	6
Journal	Brain Research
Volume	948
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(02)03056-1
Publication status	Published - 2002 Sept 6
Externally published	Yes

Keywords

Bat
Frequency selectivity
Inferior colliculus
Pulse repetition rate

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(02)03056-1

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title = "GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus",

abstract = "This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.",

keywords = "Bat, Frequency selectivity, Inferior colliculus, Pulse repetition rate",

author = "Jen, {Philip H.S.} and Wu, {Chung Hsin} and Luan, {Rui Hong} and Xiaoming Zhou",

note = "Funding Information: This work was supported by a research grant from the National Science Foundation (NSF IBN 9907610) and matching funds from the College of Arts and Sciences and the Division of Biological Sciences of the University of Missouri.",

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AU - Jen, Philip H.S.

AU - Wu, Chung Hsin

AU - Luan, Rui Hong

AU - Zhou, Xiaoming

N1 - Funding Information: This work was supported by a research grant from the National Science Foundation (NSF IBN 9907610) and matching funds from the College of Arts and Sciences and the Division of Biological Sciences of the University of Missouri.

PY - 2002/9/6

Y1 - 2002/9/6

N2 - This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.

AB - This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.

KW - Bat

KW - Frequency selectivity

KW - Inferior colliculus

KW - Pulse repetition rate

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GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus

Abstract

Keywords

ASJC Scopus subject areas

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