GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus

Philip H.S. Jen, Chung Hsin Wu, Rui Hong Luan, Xiaoming Zhou

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalBrain Research
Volume948
Issue number1-2
DOIs
Publication statusPublished - 2002 Sep 6

Fingerprint

Inferior Colliculi
Heart Rate
Bicuculline
Neurons

Keywords

  • Bat
  • Frequency selectivity
  • Inferior colliculus
  • Pulse repetition rate

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Cite this

GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus. / Jen, Philip H.S.; Wu, Chung Hsin; Luan, Rui Hong; Zhou, Xiaoming.

In: Brain Research, Vol. 948, No. 1-2, 06.09.2002, p. 159-164.

Research output: Contribution to journalArticle

@article{017bd9c58b444f63bcd3f1d7b30a858b,
title = "GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus",
abstract = "This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50{\%} of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.",
keywords = "Bat, Frequency selectivity, Inferior colliculus, Pulse repetition rate",
author = "Jen, {Philip H.S.} and Wu, {Chung Hsin} and Luan, {Rui Hong} and Xiaoming Zhou",
year = "2002",
month = "9",
day = "6",
doi = "10.1016/S0006-8993(02)03056-1",
language = "English",
volume = "948",
pages = "159--164",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1-2",

}

TY - JOUR

T1 - GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus

AU - Jen, Philip H.S.

AU - Wu, Chung Hsin

AU - Luan, Rui Hong

AU - Zhou, Xiaoming

PY - 2002/9/6

Y1 - 2002/9/6

N2 - This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.

AB - This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.

KW - Bat

KW - Frequency selectivity

KW - Inferior colliculus

KW - Pulse repetition rate

UR - http://www.scopus.com/inward/record.url?scp=0037032106&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0037032106&partnerID=8YFLogxK

U2 - 10.1016/S0006-8993(02)03056-1

DO - 10.1016/S0006-8993(02)03056-1

M3 - Article

C2 - 12383969

AN - SCOPUS:0037032106

VL - 948

SP - 159

EP - 164

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1-2

ER -