GABAergic inhibition contributes to pulse repetition rate-dependent frequency selectivity in the inferior colliculus of the big brown bat, Eptesicus fuscus

Philip H.S. Jen, Chung Hsin Wu, Rui Hong Luan, Xiaoming Zhou

Research output: Contribution to journalArticle

21 Citations (Scopus)


This study examined the effect of bicuculline application on sharpness of frequency tuning curves (FTCs) of bat inferior collicular neurons plotted under three different pulse repetition rates (PRRs) of 10, 30 and 90 pulses per second. The sharpness of FTCs of collicular neurons, which was expressed in Qn (Q10, Q20, Q30) and bandwidths (90, 75 and 50% of the maximal response at the best frequency), improved with increasing PRR. However, this PRR-dependent frequency selectivity of collicular neurons was abolished during bicuculline application. This observation suggests that GABAergic inhibition contributes more effectively to sharpening of FTCs at higher than at lower PRRs.

Original languageEnglish
Pages (from-to)159-164
Number of pages6
JournalBrain Research
Issue number1-2
Publication statusPublished - 2002 Sep 6



  • Bat
  • Frequency selectivity
  • Inferior colliculus
  • Pulse repetition rate

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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