Frequency-specific alternations in the amplitude of low-frequency fluctuations in schizophrenia

Rongjun Yu, Yi Ling Chien, Hsiao Lan Sharon Wang, Chih Min Liu, Chen Chung Liu, Tzung Jeng Hwang, Ming H. Hsieh, Hai Gwo Hwu, Wen Yih Isaac Tseng

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120 Citations (Scopus)

Abstract

Schizophrenia has been associated with abnormal task-related brain activation in sensory and motor regions as well as social cognition network. Recently, two studies investigated temporal correlation between resting-state functional magnetic resonance imaging (R-fMRI) low-frequency oscillations (LFOs) in schizophrenia but reported mixed results. This may be due to the different frequency bands used in these studies. Here we utilized R-fMRI to measure the amplitude of low-frequency fluctuations (ALFF) and fractional ALFF (fALFF) in three different frequency bands (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.08 Hz; and typical band: 0.01-0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. We showed that there were significant differences in ALFF/fALFF between the two bands (slow-5 and slow-4) in regions including basal ganglia, midbrain, and ventromedial prefrontal cortex. Importantly, we also identified significant interaction between frequency bands and groups in inferior occipital gyrus, precunus, and thalamus. The results suggest that the abnormalities of LFOs in schizophrenia is dependent on the frequency band and suggest that future studies should take the different frequency bands into account when measure intrinsic brain activity. Hum Brain Mapp 35:627-637, 2014.

Original languageEnglish
Pages (from-to)627-637
Number of pages11
JournalHuman Brain Mapping
Volume35
Issue number2
DOIs
Publication statusPublished - 2014 Feb 1

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Keywords

  • Basal ganglia
  • Low-frequency fluctuation
  • MRI
  • Prefrontal cortex
  • Resting state
  • Schizophrenia

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Yu, R., Chien, Y. L., Wang, H. L. S., Liu, C. M., Liu, C. C., Hwang, T. J., Hsieh, M. H., Hwu, H. G., & Tseng, W. Y. I. (2014). Frequency-specific alternations in the amplitude of low-frequency fluctuations in schizophrenia. Human Brain Mapping, 35(2), 627-637. https://doi.org/10.1002/hbm.22203