Frequency Dependent Alterations in Regional Homogeneity of Baseline Brain Activity in Schizophrenia

Rongjun Yu, Ming H. Hsieh, Hsiao Lan Sharon Wang, Chih Min Liu, Chen Chung Liu, Tzung Jeng Hwang, Yi Ling Chien, Hai Gwo Hwu, Wen Yih Isaac Tseng

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Abstract

Low frequency oscillations are essential in cognitive function impairment in schizophrenia. While functional connectivity can reveal the synchronization between distant brain regions, the regional abnormalities in task-independent baseline brain activity are less clear, especially in specific frequency bands. Here, we used a regional homogeneity (ReHo) method combined with resting-state functional magnetic resonance imaging to investigate low frequency spontaneous neural activity in the three different frequency bands (slow-5:0.01-0.027 Hz; slow-4:0.027-0.08 Hz; and typical band: 0.01-0.08 Hz) in 69 patients with schizophrenia and 62 healthy controls. Compared with controls, schizophrenia patients exhibited decreased ReHo in the precentral gyrus, middle occipital gyrus, and posterior insula, whereas increased ReHo in the medial prefrontal cortex and anterior insula. Significant differences in ReHo between the two bands were found in fusiform gyrus and superior frontal gyrus (slow-4> slow-5), and in basal ganglia, parahippocampus, and dorsal middle prefrontal gyrus (slow-5> slow-4). Importantly, we identified significant interaction between frequency bands and groups in the inferior occipital gyrus and caudate body. This study demonstrates that ReHo changes in schizophrenia are widespread and frequency dependent.

Original languageEnglish
Article numbere57516
JournalPloS one
Volume8
Issue number3
DOIs
Publication statusPublished - 2013 Mar 6
Externally publishedYes

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ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Cite this

Yu, R., Hsieh, M. H., Wang, H. L. S., Liu, C. M., Liu, C. C., Hwang, T. J., Chien, Y. L., Hwu, H. G., & Tseng, W. Y. I. (2013). Frequency Dependent Alterations in Regional Homogeneity of Baseline Brain Activity in Schizophrenia. PloS one, 8(3), [e57516]. https://doi.org/10.1371/journal.pone.0057516