Fragile X Mental Retardation-1 Knockout Zebrafish Shows Precocious Development in Social Behavior

Yao Ju Wu, Mao Ting Hsu, Ming Chong Ng, Tamara G. Amstislavskaya, Maria A. Tikhonova, Yi Ling Yang, Kwok Tung Lu

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Fragile X syndrome (FXS) is a generally hereditary form of human mental retardation that is caused by triplet repeat expansion (CGG) mutation in fragile X mental retardation 1 (fmr1) gene promoter and that results in the absence of the fragile X mental retardation protein (FMRP) expression. The common symptoms of FXS patients include learning disabilities, anxiety, autistic behaviors, as well as other behavioral abnormalities. Our previous results demonstrated the behavioral abnormalities in fmr1 knockout (KO) zebrafish such as fear memory impairment and autism-like behavior. Here, we studied the functional role of fmr1 gene on the development of social behavior by behavioral experiments, including shoaling behavior, shoaling preference, light/dark test, and novel tank task. Our results demonstrated that precocious development of shoaling behavior is found in fmr1 KO zebrafish without affecting the shoaling preference on conspecific zebrafish. The shoaling behavior appeared after 14 days postfertilization (dpf), and the level of shoaling elevated in fmr1 KO zebrafish. Furthermore, the fmr1 KO zebrafish at 28 dpf expressed higher anxiety level in novel tank task. These results suggest that the change of shoaling behavior in fmr1 KO zebrafish may result from hyperactivity and an increase of anxiety.

Original languageEnglish
Pages (from-to)438-443
Number of pages6
JournalZebrafish
Volume14
Issue number5
DOIs
Publication statusPublished - 2017 Oct 1

Fingerprint

Social Behavior
Zebrafish
social behavior
Danio rerio
Intellectual Disability
early development
anxiety
Fragile X Syndrome
Anxiety
Fragile X Mental Retardation Protein
behavior change
fearfulness
Trinucleotide Repeats
signs and symptoms (animals and humans)
Learning Disorders
genes
learning
Autistic Disorder
protein synthesis
promoter regions

Keywords

  • fragile X mental retardation protein
  • shoaling preference behavior
  • social behavior
  • zebrafish

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Developmental Biology

Cite this

Wu, Y. J., Hsu, M. T., Ng, M. C., Amstislavskaya, T. G., Tikhonova, M. A., Yang, Y. L., & Lu, K. T. (2017). Fragile X Mental Retardation-1 Knockout Zebrafish Shows Precocious Development in Social Behavior. Zebrafish, 14(5), 438-443. https://doi.org/10.1089/zeb.2017.1446

Fragile X Mental Retardation-1 Knockout Zebrafish Shows Precocious Development in Social Behavior. / Wu, Yao Ju; Hsu, Mao Ting; Ng, Ming Chong; Amstislavskaya, Tamara G.; Tikhonova, Maria A.; Yang, Yi Ling; Lu, Kwok Tung.

In: Zebrafish, Vol. 14, No. 5, 01.10.2017, p. 438-443.

Research output: Contribution to journalArticle

Wu, YJ, Hsu, MT, Ng, MC, Amstislavskaya, TG, Tikhonova, MA, Yang, YL & Lu, KT 2017, 'Fragile X Mental Retardation-1 Knockout Zebrafish Shows Precocious Development in Social Behavior', Zebrafish, vol. 14, no. 5, pp. 438-443. https://doi.org/10.1089/zeb.2017.1446
Wu YJ, Hsu MT, Ng MC, Amstislavskaya TG, Tikhonova MA, Yang YL et al. Fragile X Mental Retardation-1 Knockout Zebrafish Shows Precocious Development in Social Behavior. Zebrafish. 2017 Oct 1;14(5):438-443. https://doi.org/10.1089/zeb.2017.1446
Wu, Yao Ju ; Hsu, Mao Ting ; Ng, Ming Chong ; Amstislavskaya, Tamara G. ; Tikhonova, Maria A. ; Yang, Yi Ling ; Lu, Kwok Tung. / Fragile X Mental Retardation-1 Knockout Zebrafish Shows Precocious Development in Social Behavior. In: Zebrafish. 2017 ; Vol. 14, No. 5. pp. 438-443.
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