Foxp2 regulates neuronal differentiation and neuronal subtype specification

Yi Chi Chiu, Ming Yang Li, Yuan Hsuan Liu, Jing Ya Ding, Jenn Yah Yu, Tsu Wei Wang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)


Mutations of the transcription factor FOXP2 in humans cause a severe speech and language disorder. Disruption of Foxp2 in songbirds or mice also leads to deficits in song learning or ultrasonic vocalization, respectively. These data suggest that Foxp2 plays important roles in the developing nervous system. However, the mechanism of Foxp2 in regulating neural development remains elusive. In the current study, we found that Foxp2 increased neuronal differentiation without affecting cell proliferation and cell survival in primary neural progenitors from embryonic forebrains. Foxp2 induced the expression of platelet-derived growth factor receptor α, which mediated the neurognic effect of Foxp2. In addition, Foxp2 positively regulated the differentiation of medium spiny neurons derived from the lateral ganglionic eminence and negatively regulated the formation of interneurons derived from dorsal medial ganglionic eminence by interacting with the Sonic hedgehog pathway. Taken together, our results suggest that Foxp2 regulates multiple aspects of neuronal development in the embryonic forebrain.

Original languageEnglish
Pages (from-to)723-738
Number of pages16
JournalDevelopmental Neurobiology
Issue number7
Publication statusPublished - 2014 Jul


  • Forebrain
  • Foxp2
  • Neurogenesis
  • PDGF receptor
  • Shh

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience


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