Foxp2 regulates neuronal differentiation and neuronal subtype specification

Yi Chi Chiu, Ming Yang Li, Yuan Hsuan Liu, Jing Ya Ding, Jenn Yah Yu, Tsu-Wei Wang

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Mutations of the transcription factor FOXP2 in humans cause a severe speech and language disorder. Disruption of Foxp2 in songbirds or mice also leads to deficits in song learning or ultrasonic vocalization, respectively. These data suggest that Foxp2 plays important roles in the developing nervous system. However, the mechanism of Foxp2 in regulating neural development remains elusive. In the current study, we found that Foxp2 increased neuronal differentiation without affecting cell proliferation and cell survival in primary neural progenitors from embryonic forebrains. Foxp2 induced the expression of platelet-derived growth factor receptor α, which mediated the neurognic effect of Foxp2. In addition, Foxp2 positively regulated the differentiation of medium spiny neurons derived from the lateral ganglionic eminence and negatively regulated the formation of interneurons derived from dorsal medial ganglionic eminence by interacting with the Sonic hedgehog pathway. Taken together, our results suggest that Foxp2 regulates multiple aspects of neuronal development in the embryonic forebrain.

Original languageEnglish
Pages (from-to)723-738
Number of pages16
JournalDevelopmental Neurobiology
Volume74
Issue number7
DOIs
Publication statusPublished - 2014 Jan 1

Fingerprint

Prosencephalon
Language Disorders
Platelet-Derived Growth Factor Receptors
Speech Disorders
Median Eminence
Songbirds
Hedgehogs
Interneurons
Music
Ultrasonics
Nervous System
Embryonic Development
Cell Survival
Transcription Factors
Cell Proliferation
Learning
Neurons
Mutation

Keywords

  • Forebrain
  • Foxp2
  • Neurogenesis
  • PDGF receptor
  • Shh

ASJC Scopus subject areas

  • Developmental Neuroscience
  • Cellular and Molecular Neuroscience

Cite this

Foxp2 regulates neuronal differentiation and neuronal subtype specification. / Chiu, Yi Chi; Li, Ming Yang; Liu, Yuan Hsuan; Ding, Jing Ya; Yu, Jenn Yah; Wang, Tsu-Wei.

In: Developmental Neurobiology, Vol. 74, No. 7, 01.01.2014, p. 723-738.

Research output: Contribution to journalArticle

Chiu, Yi Chi ; Li, Ming Yang ; Liu, Yuan Hsuan ; Ding, Jing Ya ; Yu, Jenn Yah ; Wang, Tsu-Wei. / Foxp2 regulates neuronal differentiation and neuronal subtype specification. In: Developmental Neurobiology. 2014 ; Vol. 74, No. 7. pp. 723-738.
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