Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes

Yi Ru Chen; Ganapuram Madhusudhan Reddy; Shao Hao Hong; Ying Zheng Wang; Jhen Kuei Yu; Wenwei Lin

doi:10.1002/anie.201700945

Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes

Yi Ru Chen, Ganapuram Madhusudhan Reddy, Shao Hao Hong, Ying Zheng Wang, Jhen Kuei Yu, Wenwei Lin^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

A series of stable phosphonium salts have been synthesized via a novel four-component reaction of an arene nucleophile, 2-heteroatom substituted aryl aldehyde, and phosphine in presence of an acid. The phosphonium salts thus obtained were utilized for the synthesis of a variety of bis-heteroarenes, providing an efficient alternative method to the classical cross-coupling strategies.

Original language	English
Pages (from-to)	5106-5110
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	56
Issue number	18
DOIs	https://doi.org/10.1002/anie.201700945
Publication status	Published - 2017 Apr 24

Keywords

Wittig reactions
bis-heteroarenes
cross-coupling
multicomponent reactions
organophosphonium salts

ASJC Scopus subject areas

Catalysis
General Chemistry

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10.1002/anie.201700945

Cite this

Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes. / Chen, Yi Ru; Reddy, Ganapuram Madhusudhan; Hong, Shao Hao et al.
In: Angewandte Chemie - International Edition, Vol. 56, No. 18, 24.04.2017, p. 5106-5110.

Research output: Contribution to journal › Article › peer-review

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abstract = "A series of stable phosphonium salts have been synthesized via a novel four-component reaction of an arene nucleophile, 2-heteroatom substituted aryl aldehyde, and phosphine in presence of an acid. The phosphonium salts thus obtained were utilized for the synthesis of a variety of bis-heteroarenes, providing an efficient alternative method to the classical cross-coupling strategies.",

keywords = "Wittig reactions, bis-heteroarenes, cross-coupling, multicomponent reactions, organophosphonium salts",

author = "Chen, {Yi Ru} and Reddy, {Ganapuram Madhusudhan} and Hong, {Shao Hao} and Wang, {Ying Zheng} and Yu, {Jhen Kuei} and Wenwei Lin",

note = "Publisher Copyright: {\textcopyright} 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",

year = "2017",

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AU - Hong, Shao Hao

AU - Wang, Ying Zheng

AU - Yu, Jhen Kuei

AU - Lin, Wenwei

PY - 2017/4/24

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N2 - A series of stable phosphonium salts have been synthesized via a novel four-component reaction of an arene nucleophile, 2-heteroatom substituted aryl aldehyde, and phosphine in presence of an acid. The phosphonium salts thus obtained were utilized for the synthesis of a variety of bis-heteroarenes, providing an efficient alternative method to the classical cross-coupling strategies.

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KW - multicomponent reactions

KW - organophosphonium salts

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Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes

Abstract

Keywords

ASJC Scopus subject areas

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CCDC 1527603: Experimental Crystal Structure Determination

CCDC 1403386: Experimental Crystal Structure Determination

CCDC 1403240: Experimental Crystal Structure Determination

Cite this

Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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Fingerprint

Datasets

CCDC 1527603: Experimental Crystal Structure Determination

CCDC 1403386: Experimental Crystal Structure Determination

CCDC 1403240: Experimental Crystal Structure Determination

Cite this