Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes

Yi Ru Chen, Ganapuram Madhusudhan Reddy, Shao Hao Hong, Ying Zheng Wang, Jhen Kuei Yu, Wen-Wei Lin

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A series of stable phosphonium salts have been synthesized via a novel four-component reaction of an arene nucleophile, 2-heteroatom substituted aryl aldehyde, and phosphine in presence of an acid. The phosphonium salts thus obtained were utilized for the synthesis of a variety of bis-heteroarenes, providing an efficient alternative method to the classical cross-coupling strategies.

Original languageEnglish
Pages (from-to)5106-5110
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number18
DOIs
Publication statusPublished - 2017 Jan 1

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phosphine
Salts
Nucleophiles
Aldehydes
Acids

Keywords

  • Wittig reactions
  • bis-heteroarenes
  • cross-coupling
  • multicomponent reactions
  • organophosphonium salts

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Cite this

Four-Component Synthesis of Phosphonium Salts : Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes. / Chen, Yi Ru; Reddy, Ganapuram Madhusudhan; Hong, Shao Hao; Wang, Ying Zheng; Yu, Jhen Kuei; Lin, Wen-Wei.

In: Angewandte Chemie - International Edition, Vol. 56, No. 18, 01.01.2017, p. 5106-5110.

Research output: Contribution to journalArticle

Chen, Yi Ru ; Reddy, Ganapuram Madhusudhan ; Hong, Shao Hao ; Wang, Ying Zheng ; Yu, Jhen Kuei ; Lin, Wen-Wei. / Four-Component Synthesis of Phosphonium Salts : Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes. In: Angewandte Chemie - International Edition. 2017 ; Vol. 56, No. 18. pp. 5106-5110.
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