Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes

Yi Ru Chen, Ganapuram Madhusudhan Reddy, Shao Hao Hong, Ying Zheng Wang, Jhen Kuei Yu, Wenwei Lin

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

A series of stable phosphonium salts have been synthesized via a novel four-component reaction of an arene nucleophile, 2-heteroatom substituted aryl aldehyde, and phosphine in presence of an acid. The phosphonium salts thus obtained were utilized for the synthesis of a variety of bis-heteroarenes, providing an efficient alternative method to the classical cross-coupling strategies.

Original languageEnglish
Pages (from-to)5106-5110
Number of pages5
JournalAngewandte Chemie - International Edition
Volume56
Issue number18
DOIs
Publication statusPublished - 2017 Jan 1

Keywords

  • Wittig reactions
  • bis-heteroarenes
  • cross-coupling
  • multicomponent reactions
  • organophosphonium salts

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Four-Component Synthesis of Phosphonium Salts: Application Toward an Alternative Approach to Cross-Coupling for the Synthesis of Bis-Heteroarenes'. Together they form a unique fingerprint.

  • Cite this