FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)-C(34) fragment of FK-506, FR-900520, and FR-900523

Amos B. Smith; Karl J. Hale; Leif M. Laakso; Kwunmin Chen; Antoni Riéra

doi:10.1016/S0040-4039(01)93398-2

FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)-C(34) fragment of FK-506, FR-900520, and FR-900523

Amos B. Smith^*
, Karl J. Hale
, Leif M. Laakso
, Kwunmin Chen
, Antoni Riéra

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

80 Citations (Scopus)

Abstract

An efficient asymmetric synthesis of the C(24)-C(34) fragment of the FK-506 family of immunosuppressants has been achieved.

Original language	English
Pages (from-to)	6963-6966
Number of pages	4
Journal	Tetrahedron Letters
Volume	30
Issue number	50
DOIs	https://doi.org/10.1016/S0040-4039(01)93398-2
Publication status	Published - 1989
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)93398-2

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@article{66455659a1894759a478624356d5981c,

title = "FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)-C(34) fragment of FK-506, FR-900520, and FR-900523",

abstract = "An efficient asymmetric synthesis of the C(24)-C(34) fragment of the FK-506 family of immunosuppressants has been achieved.",

author = "Smith, \{Amos B.\} and Hale, \{Karl J.\} and Laakso, \{Leif M.\} and Kwunmin Chen and Antoni Ri{\'e}ra",

note = "Funding Information: Acknowledgement\% We thank the National Institutes of Health (Institute of General Medical Sciences) for support of this investigation through grant no. GM29028. We are also indebted to Drs. G. Furst, P. Carroll, and J. Dykins and Mr. J. Wood for assistance in obtaining NMR spectra, X-ray crystallographic analyses, and mass spectra.",

year = "1989",

doi = "10.1016/S0040-4039(01)93398-2",

language = "English",

volume = "30",

pages = "6963--6966",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "50",

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TY - JOUR

T1 - FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)-C(34) fragment of FK-506, FR-900520, and FR-900523

AU - Smith, Amos B.

AU - Hale, Karl J.

AU - Laakso, Leif M.

AU - Chen, Kwunmin

AU - Riéra, Antoni

N1 - Funding Information: Acknowledgement% We thank the National Institutes of Health (Institute of General Medical Sciences) for support of this investigation through grant no. GM29028. We are also indebted to Drs. G. Furst, P. Carroll, and J. Dykins and Mr. J. Wood for assistance in obtaining NMR spectra, X-ray crystallographic analyses, and mass spectra.

PY - 1989

Y1 - 1989

N2 - An efficient asymmetric synthesis of the C(24)-C(34) fragment of the FK-506 family of immunosuppressants has been achieved.

AB - An efficient asymmetric synthesis of the C(24)-C(34) fragment of the FK-506 family of immunosuppressants has been achieved.

UR - https://www.scopus.com/pages/publications/0024791572

UR - https://www.scopus.com/pages/publications/0024791572#tab=citedBy

U2 - 10.1016/S0040-4039(01)93398-2

DO - 10.1016/S0040-4039(01)93398-2

M3 - Article

AN - SCOPUS:0024791572

SN - 0040-4039

VL - 30

SP - 6963

EP - 6966

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 50

ER -

FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)-C(34) fragment of FK-506, FR-900520, and FR-900523

Abstract

ASJC Scopus subject areas

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