FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)-C(34) fragment of FK-506, FR-900520, and FR-900523

Amos B. Smith, Karl J. Hale, Leif M. Laakso, Kwunmin Chen, Antoni Riéra

Research output: Contribution to journal › Article

72 Citations (Scopus)

Abstract

An efficient asymmetric synthesis of the C(24)-C(34) fragment of the FK-506 family of immunosuppressants has been achieved.

Original languageEnglish
Pages (from-to)6963-6966
Number of pages4
JournalTetrahedron Letters
Volume30
Issue number50
DOIs
Publication statusPublished - 1989 Jan 1

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Tacrolimus
Immunosuppressive Agents
immunomycin
FR 900523

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

Cite this

FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)-C(34) fragment of FK-506, FR-900520, and FR-900523. / Smith, Amos B.; Hale, Karl J.; Laakso, Leif M.; Chen, Kwunmin; Riéra, Antoni.

In: Tetrahedron Letters, Vol. 30, No. 50, 01.01.1989, p. 6963-6966.

Research output: Contribution to journal › Article

Smith, AB, Hale, KJ, Laakso, LM, Chen, K & Riéra, A 1989, 'FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)-C(34) fragment of FK-506, FR-900520, and FR-900523', Tetrahedron Letters, vol. 30, no. 50, pp. 6963-6966. https://doi.org/10.1016/S0040-4039(01)93398-2
Smith AB, Hale KJ, Laakso LM, Chen K, Riéra A. FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)-C(34) fragment of FK-506, FR-900520, and FR-900523. Tetrahedron Letters. 1989 Jan 1;30(50):6963-6966. https://doi.org/10.1016/S0040-4039(01)93398-2
Smith, Amos B. ; Hale, Karl J. ; Laakso, Leif M. ; Chen, Kwunmin ; Riéra, Antoni. / FK-506 synthetic studies. 3. An efficient asymmetric synthesis of the C(24)-C(34) fragment of FK-506, FR-900520, and FR-900523. In: Tetrahedron Letters. 1989 ; Vol. 30, No. 50. pp. 6963-6966.
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