Recently, the different types of biliary stent are widely used to provide a longer patency and are more cost-effective for patients surviving. In this study, the design of biliary stent can be fabricated by femtosecond laser ablation in wavelength of 1035 nm. Here the pulsewidth of this laser is smaller than heat diffusion time to reduce heat-affected zone (HAZ). And then, the smart material of nitinol (Ni-Ti) alloy is used to fabricate the stent for medicine application of cholangiocarcinoma. The experimental results show the good quality edge of stent can be obtained via the nonlinear ablation process; however, the kerf surface of stent still can generate some nano-scale structures after this process.