FeCl3 catalyzed regioselective C -alkylation of indolylnitroalkenes with amino group substituted arenes

Manoj R. Zanwar; Veerababurao Kavala; Sachin D. Gawande; Chun Wei Kuo; Wen Chang Huang; Ting Shen Kuo; Hsiu Ni Huang; Chiu Hui He; Ching Fa Yao

doi:10.1021/jo4025368

FeCl₃ catalyzed regioselective C -alkylation of indolylnitroalkenes with amino group substituted arenes

Manoj R. Zanwar, Veerababurao Kavala, Sachin D. Gawande, Chun Wei Kuo, Wen Chang Huang, Ting Shen Kuo, Hsiu Ni Huang, Chiu Hui He, Ching Fa Yao

Department of Chemistry

Research output: Contribution to journal › Article

4 Citations (Scopus)

Abstract

An efficient FeCl₃ catalyzed protocol for the synthesis of amino functionalized indolylnitroalkanes from easily available precursor indolylnitroalkenes and substituted amines has been developed. Regioselective C-alkylation in the presence of free amino substituted arenes occurred. The scope of this methodology shows good functional group tolerance, and further, this protocol was used to prepare indolylquinoline derivatives.

Original language	English
Pages (from-to)	1842-1849
Number of pages	8
Journal	Journal of Organic Chemistry
Volume	79
Issue number	4
DOIs	https://doi.org/10.1021/jo4025368
Publication status	Published - 2014 Feb 21

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Alkylation

Functional groups

Amines

Derivatives

ASJC Scopus subject areas

Organic Chemistry

Cite this

Zanwar, M. R., Kavala, V., Gawande, S. D., Kuo, C. W., Huang, W. C., Kuo, T. S., ... Yao, C. F. (2014). FeCl₃ catalyzed regioselective C -alkylation of indolylnitroalkenes with amino group substituted arenes. Journal of Organic Chemistry, 79(4), 1842-1849. https://doi.org/10.1021/jo4025368

FeCl₃ catalyzed regioselective C -alkylation of indolylnitroalkenes with amino group substituted arenes. / Zanwar, Manoj R.; Kavala, Veerababurao; Gawande, Sachin D.; Kuo, Chun Wei; Huang, Wen Chang; Kuo, Ting Shen; Huang, Hsiu Ni; He, Chiu Hui; Yao, Ching Fa.

In: Journal of Organic Chemistry, Vol. 79, No. 4, 21.02.2014, p. 1842-1849.

Research output: Contribution to journal › Article

Zanwar, MR, Kavala, V, Gawande, SD, Kuo, CW, Huang, WC, Kuo, TS, Huang, HN, He, CH & Yao, CF 2014, 'FeCl₃ catalyzed regioselective C -alkylation of indolylnitroalkenes with amino group substituted arenes', Journal of Organic Chemistry, vol. 79, no. 4, pp. 1842-1849. https://doi.org/10.1021/jo4025368

Zanwar MR, Kavala V, Gawande SD, Kuo CW, Huang WC, Kuo TS et al. FeCl₃ catalyzed regioselective C -alkylation of indolylnitroalkenes with amino group substituted arenes. Journal of Organic Chemistry. 2014 Feb 21;79(4):1842-1849. https://doi.org/10.1021/jo4025368

Zanwar, Manoj R. ; Kavala, Veerababurao ; Gawande, Sachin D. ; Kuo, Chun Wei ; Huang, Wen Chang ; Kuo, Ting Shen ; Huang, Hsiu Ni ; He, Chiu Hui ; Yao, Ching Fa. / FeCl₃ catalyzed regioselective C -alkylation of indolylnitroalkenes with amino group substituted arenes. In: Journal of Organic Chemistry. 2014 ; Vol. 79, No. 4. pp. 1842-1849.

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10.1021/jo4025368