Abstract
C-Alkylation of 2-hydroxy-1,4-naphthoquinone to various nitroolefins was achieved under catalyst-free employing 'on water' conditions. The mechanism for the formation can be explained on the basis of dual activation of nitroalkene and 2-hydroxy-1,4-naphthoquinones via hydrogen bonding. Simple reaction conditions, high yields of the products, and environmentally benign medium are attractive features of this method.
| Original language | English |
|---|---|
| Pages (from-to) | 5116-5119 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 50 |
| Issue number | 36 |
| DOIs | |
| Publication status | Published - 2009 Sep 9 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Barange, D. K., Kavala, V., Raju, B. R., Kuo, C. W., Tseng, C., Tu, Y. C., & Yao, C. F. (2009). Facile and highly efficient method for the C-alkylation of 2-hydroxy-1,4-naphthoquinone to nitroalkenes under catalyst-free 'on water' conditions. Tetrahedron Letters, 50(36), 5116-5119. https://doi.org/10.1016/j.tetlet.2009.06.107