Expression of type VI adenylyl cyclase in the central nervous system: Implication for a potential regulator of multiple signals in different neurotransmitter systems

Fu Chin Liu, Gour Cheng Wu, Sung Tsang Hsieh, Hsing Lin Lai, Hsiao Fang Wang, Tsu Wei Wang, Yijuang Chern

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The aim of this study was to investigate the distribution of a calcium-inhibitable adenylyl cyclase type VI (type VI AC) in the central nervous system using an antiserum directed against the N-terminus of type VI AC. Our results indicate that type VI AC immunoreactivity is generally expressed in many brain regions with different levels of intensity. Most interestingly, the majority of the detected type VI AC immunoreactivity is present in cells of neuronal phenotype. Double immunostaining of type VI AC and markers of various neurotransmitter systems suggest that type VI AC might participate in regulation of the classical neurotransmitter systems and therefore appeared to play a very important role in the central nervous system. Copyright (C) 1998 Federation of European Biochemical Societies.

Original languageEnglish
Pages (from-to)92-98
Number of pages7
JournalFEBS Letters
Issue number1
Publication statusPublished - 1998 Sep 25



  • Adenylyl cyclase
  • Brain
  • Calcium
  • Immunocytochemistry
  • Protein kinase C
  • cAMP

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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