Experimental study of sensitivity enhancement in SPR biosensors by use of zinc oxide intermediary layers

Nan Fu Chiu, Amit Singh, Nathan Nelson-Fitzpatrick, Sarang Dutt, Stephane Evoy, Chii Wann Lin

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Abstract

    We report a novel design for the intermediary layer of surface plasmon resonance (SPR) devices that use high refractive index and high-transmittance zinc oxide (ZnO) dielectric layers to enhance the signal quality and improve the full width at half-maximum (FWHM) of the reflectivity curve. We optimized the design of ZnO thin films using different sputtering parameters and performed analytical comparisons with conventional intermediary layers of chromium (Cr) as well as indium tin oxide (ITO). The study is based on application of the Fresnel equation, which provides an explanation and verification for the observed SPR narrow-width curve and optical transmittance spectra displayed by (ZnO/Au)-1, (Cr/Au)-4 and (ITO/Au)-5 devices. On exposure to ethanol, the (ZnO/Au)-1 device showed a two-fold decrease in FWHM and a 4.5-fold larger shift in intensity interrogation. The (ZnO/Au)-1 device exhibits a wider linearity range and much higher sensitivity. They also exhibit a good linear relationship between angle and concentration dependence in the tested range. We show that these advances represent a novel and simple method for preparing high-sensitivity, high-resolution SPR biosensors for accurate and specific bio-molecular detection.

    Original languageEnglish
    Title of host publicationTechnical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
    Pages86-89
    Number of pages4
    Volume3
    Publication statusPublished - 2011
    EventNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 - Boston, MA, United States
    Duration: 2011 Jun 132011 Jun 16

    Other

    OtherNanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011
    CountryUnited States
    CityBoston, MA
    Period11/6/1311/6/16

    Fingerprint

    Zinc Oxide
    Surface plasmon resonance
    Zinc oxide
    Biosensors
    Chromium
    Full width at half maximum
    Tin oxides
    Indium
    Opacity
    Oxide films
    Sputtering
    Refractive index
    Ethanol
    Thin films

    Keywords

    • Angular interrogation mode
    • Biosensor
    • Full Width at Half-Maximum (FWHM)
    • Intensity interrogation mode
    • Intermediary layer
    • Refractive index unit (RIU)
    • Surface plasmon resonance (SPR)
    • Zinc oxide (ZnO)

    ASJC Scopus subject areas

    • Bioengineering
    • Biomedical Engineering
    • Electrical and Electronic Engineering

    Cite this

    Chiu, N. F., Singh, A., Nelson-Fitzpatrick, N., Dutt, S., Evoy, S., & Lin, C. W. (2011). Experimental study of sensitivity enhancement in SPR biosensors by use of zinc oxide intermediary layers. In Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011 (Vol. 3, pp. 86-89)

    Experimental study of sensitivity enhancement in SPR biosensors by use of zinc oxide intermediary layers. / Chiu, Nan Fu; Singh, Amit; Nelson-Fitzpatrick, Nathan; Dutt, Sarang; Evoy, Stephane; Lin, Chii Wann.

    Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. Vol. 3 2011. p. 86-89.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

    Chiu, NF, Singh, A, Nelson-Fitzpatrick, N, Dutt, S, Evoy, S & Lin, CW 2011, Experimental study of sensitivity enhancement in SPR biosensors by use of zinc oxide intermediary layers. in Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. vol. 3, pp. 86-89, Nanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational - 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011, Boston, MA, United States, 11/6/13.
    Chiu NF, Singh A, Nelson-Fitzpatrick N, Dutt S, Evoy S, Lin CW. Experimental study of sensitivity enhancement in SPR biosensors by use of zinc oxide intermediary layers. In Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. Vol. 3. 2011. p. 86-89
    Chiu, Nan Fu ; Singh, Amit ; Nelson-Fitzpatrick, Nathan ; Dutt, Sarang ; Evoy, Stephane ; Lin, Chii Wann. / Experimental study of sensitivity enhancement in SPR biosensors by use of zinc oxide intermediary layers. Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011. Vol. 3 2011. pp. 86-89
    @inproceedings{0c03ffcf05e047868216885c11191b0a,
    title = "Experimental study of sensitivity enhancement in SPR biosensors by use of zinc oxide intermediary layers",
    abstract = "We report a novel design for the intermediary layer of surface plasmon resonance (SPR) devices that use high refractive index and high-transmittance zinc oxide (ZnO) dielectric layers to enhance the signal quality and improve the full width at half-maximum (FWHM) of the reflectivity curve. We optimized the design of ZnO thin films using different sputtering parameters and performed analytical comparisons with conventional intermediary layers of chromium (Cr) as well as indium tin oxide (ITO). The study is based on application of the Fresnel equation, which provides an explanation and verification for the observed SPR narrow-width curve and optical transmittance spectra displayed by (ZnO/Au)-1, (Cr/Au)-4 and (ITO/Au)-5 devices. On exposure to ethanol, the (ZnO/Au)-1 device showed a two-fold decrease in FWHM and a 4.5-fold larger shift in intensity interrogation. The (ZnO/Au)-1 device exhibits a wider linearity range and much higher sensitivity. They also exhibit a good linear relationship between angle and concentration dependence in the tested range. We show that these advances represent a novel and simple method for preparing high-sensitivity, high-resolution SPR biosensors for accurate and specific bio-molecular detection.",
    keywords = "Angular interrogation mode, Biosensor, Full Width at Half-Maximum (FWHM), Intensity interrogation mode, Intermediary layer, Refractive index unit (RIU), Surface plasmon resonance (SPR), Zinc oxide (ZnO)",
    author = "Chiu, {Nan Fu} and Amit Singh and Nathan Nelson-Fitzpatrick and Sarang Dutt and Stephane Evoy and Lin, {Chii Wann}",
    year = "2011",
    language = "English",
    isbn = "9781439871386",
    volume = "3",
    pages = "86--89",
    booktitle = "Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011",

    }

    TY - GEN

    T1 - Experimental study of sensitivity enhancement in SPR biosensors by use of zinc oxide intermediary layers

    AU - Chiu, Nan Fu

    AU - Singh, Amit

    AU - Nelson-Fitzpatrick, Nathan

    AU - Dutt, Sarang

    AU - Evoy, Stephane

    AU - Lin, Chii Wann

    PY - 2011

    Y1 - 2011

    N2 - We report a novel design for the intermediary layer of surface plasmon resonance (SPR) devices that use high refractive index and high-transmittance zinc oxide (ZnO) dielectric layers to enhance the signal quality and improve the full width at half-maximum (FWHM) of the reflectivity curve. We optimized the design of ZnO thin films using different sputtering parameters and performed analytical comparisons with conventional intermediary layers of chromium (Cr) as well as indium tin oxide (ITO). The study is based on application of the Fresnel equation, which provides an explanation and verification for the observed SPR narrow-width curve and optical transmittance spectra displayed by (ZnO/Au)-1, (Cr/Au)-4 and (ITO/Au)-5 devices. On exposure to ethanol, the (ZnO/Au)-1 device showed a two-fold decrease in FWHM and a 4.5-fold larger shift in intensity interrogation. The (ZnO/Au)-1 device exhibits a wider linearity range and much higher sensitivity. They also exhibit a good linear relationship between angle and concentration dependence in the tested range. We show that these advances represent a novel and simple method for preparing high-sensitivity, high-resolution SPR biosensors for accurate and specific bio-molecular detection.

    AB - We report a novel design for the intermediary layer of surface plasmon resonance (SPR) devices that use high refractive index and high-transmittance zinc oxide (ZnO) dielectric layers to enhance the signal quality and improve the full width at half-maximum (FWHM) of the reflectivity curve. We optimized the design of ZnO thin films using different sputtering parameters and performed analytical comparisons with conventional intermediary layers of chromium (Cr) as well as indium tin oxide (ITO). The study is based on application of the Fresnel equation, which provides an explanation and verification for the observed SPR narrow-width curve and optical transmittance spectra displayed by (ZnO/Au)-1, (Cr/Au)-4 and (ITO/Au)-5 devices. On exposure to ethanol, the (ZnO/Au)-1 device showed a two-fold decrease in FWHM and a 4.5-fold larger shift in intensity interrogation. The (ZnO/Au)-1 device exhibits a wider linearity range and much higher sensitivity. They also exhibit a good linear relationship between angle and concentration dependence in the tested range. We show that these advances represent a novel and simple method for preparing high-sensitivity, high-resolution SPR biosensors for accurate and specific bio-molecular detection.

    KW - Angular interrogation mode

    KW - Biosensor

    KW - Full Width at Half-Maximum (FWHM)

    KW - Intensity interrogation mode

    KW - Intermediary layer

    KW - Refractive index unit (RIU)

    KW - Surface plasmon resonance (SPR)

    KW - Zinc oxide (ZnO)

    UR - http://www.scopus.com/inward/record.url?scp=81455143975&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=81455143975&partnerID=8YFLogxK

    M3 - Conference contribution

    SN - 9781439871386

    VL - 3

    SP - 86

    EP - 89

    BT - Technical Proceedings of the 2011 NSTI Nanotechnology Conference and Expo, NSTI-Nanotech 2011

    ER -