Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia

Chiung Mei Chen; Hsien Yuan Lane; Yih Ru Wu; Long Sun Ro; Fen Lin Chen; Wei Ling Hung; Yi Ting Hou; Cheng Yueh Lin; Shu Yi Huang; I. Cheng Chen; Bing Wen Soong; Ming Liang Li; Hsiu Mei Hsieh-Li; Ming Tsan Su; Guey Jen Lee-Chen

doi:10.1016/j.schres.2005.06.018

Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia

Chiung Mei Chen, Hsien Yuan Lane^*, Yih Ru Wu, Long Sun Ro, Fen Lin Chen, Wei Ling Hung, Yi Ting Hou, Cheng Yueh Lin, Shu Yi Huang, I. Cheng Chen, Bing Wen Soong, Ming Liang Li, Hsiu Mei Hsieh-Li, Ming Tsan Su, Guey Jen Lee-Chen

^*Corresponding author for this work

Department of Life Science

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Schizophrenia has a complex and non-Mendelian mode of inheritance. Recently, trinucleotide repeat (TNR)-containing genes have been considered as the candidate genes predisposing to schizophrenia. The purpose of this study was to determine whether a genetic association could be observed between schizophrenia and the TNR polymorphisms within the KLHL1AS/SCA8, PPP2R2B/SCA12, and TBP/SCA17 genes. We studied 100 unrelated schizophrenia patients and 124 controls without evident neurodegenerative or psychiatric disorders. The overall allele frequency distributions of the KLHL1AS/SCA8 and PPP2R2B/SCA12 genes were not significantly different between the schizophrenic patients and the control subjects (P > 0.05). The allele frequency distribution in the schizophrenic patients was significantly different from that in the controls at the TBP/SCA17 gene (P = 0.0149), with an increased frequency of 36 repeats in the patients and two patients carrying 45 TNR expansions were identified. TBP/SCA17 is the TATA box binding protein gene mapped to chromosome 6q27. The study suggests that TNR expansions of the TBP/SCA17 gene may contribute to the genetic risk of schizophrenia in rare cases.

Original language	English
Pages (from-to)	131-136
Number of pages	6
Journal	Schizophrenia Research
Volume	78
Issue number	2-3
DOIs	https://doi.org/10.1016/j.schres.2005.06.018
Publication status	Published - 2005 Oct 15

Keywords

KLHL1AS/SCA8
PPP2R2B/SCA12
Schizophrenia
TBP/SCA17
Trinucleotide repeats

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.schres.2005.06.018

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Chen, C. M., Lane, H. Y., Wu, Y. R., Ro, L. S., Chen, F. L., Hung, W. L., Hou, Y. T., Lin, C. Y., Huang, S. Y., Chen, I. C., Soong, B. W., Li, M. L., Hsieh-Li, H. M., Su, M. T., & Lee-Chen, G. J. (2005). Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia. Schizophrenia Research, 78(2-3), 131-136. https://doi.org/10.1016/j.schres.2005.06.018

Chen, CM, Lane, HY, Wu, YR, Ro, LS, Chen, FL, Hung, WL, Hou, YT, Lin, CY, Huang, SY, Chen, IC, Soong, BW, Li, ML, Hsieh-Li, HM , Su, MT & Lee-Chen, GJ 2005, 'Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia', Schizophrenia Research, vol. 78, no. 2-3, pp. 131-136. https://doi.org/10.1016/j.schres.2005.06.018

@article{e40fe1b64ec04c75a22c2e2adb26c67a,

title = "Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia",

abstract = "Schizophrenia has a complex and non-Mendelian mode of inheritance. Recently, trinucleotide repeat (TNR)-containing genes have been considered as the candidate genes predisposing to schizophrenia. The purpose of this study was to determine whether a genetic association could be observed between schizophrenia and the TNR polymorphisms within the KLHL1AS/SCA8, PPP2R2B/SCA12, and TBP/SCA17 genes. We studied 100 unrelated schizophrenia patients and 124 controls without evident neurodegenerative or psychiatric disorders. The overall allele frequency distributions of the KLHL1AS/SCA8 and PPP2R2B/SCA12 genes were not significantly different between the schizophrenic patients and the control subjects (P > 0.05). The allele frequency distribution in the schizophrenic patients was significantly different from that in the controls at the TBP/SCA17 gene (P = 0.0149), with an increased frequency of 36 repeats in the patients and two patients carrying 45 TNR expansions were identified. TBP/SCA17 is the TATA box binding protein gene mapped to chromosome 6q27. The study suggests that TNR expansions of the TBP/SCA17 gene may contribute to the genetic risk of schizophrenia in rare cases.",

keywords = "KLHL1AS/SCA8, PPP2R2B/SCA12, Schizophrenia, TBP/SCA17, Trinucleotide repeats",

author = "Chen, {Chiung Mei} and Lane, {Hsien Yuan} and Wu, {Yih Ru} and Ro, {Long Sun} and Chen, {Fen Lin} and Hung, {Wei Ling} and Hou, {Yi Ting} and Lin, {Cheng Yueh} and Huang, {Shu Yi} and Chen, {I. Cheng} and Soong, {Bing Wen} and Li, {Ming Liang} and Hsieh-Li, {Hsiu Mei} and Su, {Ming Tsan} and Lee-Chen, {Guey Jen}",

note = "Funding Information: We thank the schizophrenia patients and the normal controls for participating in this study. This work was supported by grants NSC-93-3112-B-003-002 and NSC93-2314-B-182A-171 from the National Science Council, Executive Yuan, Taiwan, ORD93-2 from National Taiwan Normal University, Taipei, Taiwan, CMRPG 33108 from Chang Gung Memorial Hospital, Taipei, Taiwan, NHRI-EX-94-9405PI from the National Health Research Institutes and 94DOH004 from the National Research Program for Genomic Medicine, Taiwan.",

year = "2005",

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doi = "10.1016/j.schres.2005.06.018",

language = "English",

volume = "78",

pages = "131--136",

journal = "Schizophrenia Research",

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T1 - Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia

AU - Chen, Chiung Mei

AU - Lane, Hsien Yuan

AU - Wu, Yih Ru

AU - Ro, Long Sun

AU - Chen, Fen Lin

AU - Hung, Wei Ling

AU - Hou, Yi Ting

AU - Lin, Cheng Yueh

AU - Huang, Shu Yi

AU - Chen, I. Cheng

AU - Soong, Bing Wen

AU - Li, Ming Liang

AU - Hsieh-Li, Hsiu Mei

AU - Su, Ming Tsan

AU - Lee-Chen, Guey Jen

N1 - Funding Information: We thank the schizophrenia patients and the normal controls for participating in this study. This work was supported by grants NSC-93-3112-B-003-002 and NSC93-2314-B-182A-171 from the National Science Council, Executive Yuan, Taiwan, ORD93-2 from National Taiwan Normal University, Taipei, Taiwan, CMRPG 33108 from Chang Gung Memorial Hospital, Taipei, Taiwan, NHRI-EX-94-9405PI from the National Health Research Institutes and 94DOH004 from the National Research Program for Genomic Medicine, Taiwan.

PY - 2005/10/15

Y1 - 2005/10/15

N2 - Schizophrenia has a complex and non-Mendelian mode of inheritance. Recently, trinucleotide repeat (TNR)-containing genes have been considered as the candidate genes predisposing to schizophrenia. The purpose of this study was to determine whether a genetic association could be observed between schizophrenia and the TNR polymorphisms within the KLHL1AS/SCA8, PPP2R2B/SCA12, and TBP/SCA17 genes. We studied 100 unrelated schizophrenia patients and 124 controls without evident neurodegenerative or psychiatric disorders. The overall allele frequency distributions of the KLHL1AS/SCA8 and PPP2R2B/SCA12 genes were not significantly different between the schizophrenic patients and the control subjects (P > 0.05). The allele frequency distribution in the schizophrenic patients was significantly different from that in the controls at the TBP/SCA17 gene (P = 0.0149), with an increased frequency of 36 repeats in the patients and two patients carrying 45 TNR expansions were identified. TBP/SCA17 is the TATA box binding protein gene mapped to chromosome 6q27. The study suggests that TNR expansions of the TBP/SCA17 gene may contribute to the genetic risk of schizophrenia in rare cases.

AB - Schizophrenia has a complex and non-Mendelian mode of inheritance. Recently, trinucleotide repeat (TNR)-containing genes have been considered as the candidate genes predisposing to schizophrenia. The purpose of this study was to determine whether a genetic association could be observed between schizophrenia and the TNR polymorphisms within the KLHL1AS/SCA8, PPP2R2B/SCA12, and TBP/SCA17 genes. We studied 100 unrelated schizophrenia patients and 124 controls without evident neurodegenerative or psychiatric disorders. The overall allele frequency distributions of the KLHL1AS/SCA8 and PPP2R2B/SCA12 genes were not significantly different between the schizophrenic patients and the control subjects (P > 0.05). The allele frequency distribution in the schizophrenic patients was significantly different from that in the controls at the TBP/SCA17 gene (P = 0.0149), with an increased frequency of 36 repeats in the patients and two patients carrying 45 TNR expansions were identified. TBP/SCA17 is the TATA box binding protein gene mapped to chromosome 6q27. The study suggests that TNR expansions of the TBP/SCA17 gene may contribute to the genetic risk of schizophrenia in rare cases.

KW - KLHL1AS/SCA8

KW - PPP2R2B/SCA12

KW - Schizophrenia

KW - TBP/SCA17

KW - Trinucleotide repeats

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DO - 10.1016/j.schres.2005.06.018

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SN - 0920-9964

VL - 78

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EP - 136

JO - Schizophrenia Research

JF - Schizophrenia Research

IS - 2-3

ER -

Expanded trinucleotide repeats in the TBP/SCA17 gene mapped to chromosome 6q27 are associated with schizophrenia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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