Exo-10,10-diphenyl-2,10-camphanediol as a new chiral auxiliary in asymmetric reduction

C. J. Chen, Y. Y. Chu, Y. Y. Liao, Z. H. Tsai, C. C. Wang, K. Chen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)


Stereoselective reduction of α-keto ester derived from exo-10,10- diphenyl-2,10-camphanediol with various hydrides proceeded with high diastereoselectivities (≥ 96% de) to afford the corresponding α-hydroxy ester with excellent yields. Change of reducing reagents and molar ratio modifications leading to dramatic changes in diastereofacial selectivity were examined. The auxiliary can be recovered from the asymmetric reaction products without loss of chirality.

Original languageEnglish
Pages (from-to)1141-1144
Number of pages4
JournalTetrahedron Letters
Issue number6
Publication statusPublished - 1999 Feb 5
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry


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