Existence and stability of traveling waves in buffered systems

Je Chiang Tsai, James Sneyd

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

We study wave propagation in the buffered bistable equation, i.e., the bistable equation where the diffusing species reacts with immobile buffers that restrict its diffusion. Such a model describes wave front propagation in excitable systems where the diffusing species is buffered; in particular, the study of the propagation of waves of increased calcium concentration in a variety of cell types depends directly upon the analysis of such buffered excitability. However, despite the biological importance of these types of equations, there have been almost no analytical studies of their properties. Here, we study the question of whether or not the inclusion of multiple buffers can eliminate propagated waves. First, we prove that a unique (up to translation) traveling wave front exists. Moreover, the wave speed is also unique. Then we prove that this traveling wave front is stable, i.e., that any initial condition which vaguely resembles a traveling wave front (in a way we make precise) evolves to the unique wave front. We thus prove that multiple stationary buffers cannot prevent the existence of a traveling wave front in the buffered bistable equation and may not eliminate stable wave fronts. This suggests (although we do not prove) that the same result is true for more complex and realistic models of calcium wave propagation, a result of direct physiological relevance.

Original languageEnglish
Pages (from-to)237-265
Number of pages29
JournalSIAM Journal on Applied Mathematics
Volume66
Issue number1
DOIs
Publication statusPublished - 2006 Mar 7

Fingerprint

Traveling Wavefronts
Traveling Wave
Wave Front
Wave Propagation
Buffer
Calcium
Eliminate
Excitable Systems
Front Propagation
Excitability
Wave Speed
Initial conditions
Inclusion
Wave propagation
Propagation
Cell
Model

Keywords

  • Bistable equation
  • Calcium
  • FitzHugh-Nagumo equations
  • Reaction-diffusion equations
  • Stability
  • Traveling wave

ASJC Scopus subject areas

  • Applied Mathematics

Cite this

Existence and stability of traveling waves in buffered systems. / Tsai, Je Chiang; Sneyd, James.

In: SIAM Journal on Applied Mathematics, Vol. 66, No. 1, 07.03.2006, p. 237-265.

Research output: Contribution to journalArticle

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