TY - JOUR
T1 - Evaluation of thermo responsive magnetic nano-particles for high-Tc SQUID bio application
AU - Tanaka, S.
AU - Toriyabe, C.
AU - Torii, Y.
AU - Hatsukade, Y.
AU - Eki, T.
AU - Katsura, S.
AU - Ohnishi, N.
AU - Wan, J.
AU - Yang, S.
AU - Zhang, Y.
N1 - Funding Information:
This work was supported in part by a Grant-in-Aid for Science Research (B) from Japan Society for the Promotion of Science, and The 21st Century COE Program “Ecological Engineering for Homeostatic Human Activities” from the ministry of Education, Culture, Sports, Science and Technology.
PY - 2007/10/1
Y1 - 2007/10/1
N2 - Immunoassay or detection of biological molecules using a high sensitive SQUID and magnetic nano-particles as labeling has been recently proposed. In this method, mostly a few particles are labeled on an antibody or biological molecules. If it is possible to give much more magnetic particles to the antibody, sensitivity must notably increase. We propose the use of thermo responsive magnetic nano-particles, which can agglutinate and disperse by themselves associated with temperature. As a preliminary experiment, we investigated the properties of thermo responsive nano-particles made of Fe3O4. By detailed study on the particles using an analyzer for a distribution of particle's outer dimension in aqueous liquid, it was found that the dimension increased with temperature above 25°, and became 400 nm at 30.5°. Magnetic measurements of the particles at different conditions using high-Tc SQUID have been done. The results suggested that the particles must be dried by heat before magnetic measurement to enhance the signal from the particles.
AB - Immunoassay or detection of biological molecules using a high sensitive SQUID and magnetic nano-particles as labeling has been recently proposed. In this method, mostly a few particles are labeled on an antibody or biological molecules. If it is possible to give much more magnetic particles to the antibody, sensitivity must notably increase. We propose the use of thermo responsive magnetic nano-particles, which can agglutinate and disperse by themselves associated with temperature. As a preliminary experiment, we investigated the properties of thermo responsive nano-particles made of Fe3O4. By detailed study on the particles using an analyzer for a distribution of particle's outer dimension in aqueous liquid, it was found that the dimension increased with temperature above 25°, and became 400 nm at 30.5°. Magnetic measurements of the particles at different conditions using high-Tc SQUID have been done. The results suggested that the particles must be dried by heat before magnetic measurement to enhance the signal from the particles.
KW - FeO
KW - Immunoassay
KW - Particle
KW - SQUID
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U2 - 10.1016/j.physc.2007.04.285
DO - 10.1016/j.physc.2007.04.285
M3 - Article
AN - SCOPUS:34548441690
SN - 0921-4534
VL - 463-465
SP - 1029
EP - 1033
JO - Physica C: Superconductivity and its applications
JF - Physica C: Superconductivity and its applications
IS - SUPPL.
ER -