Evaluation of thermo responsive magnetic nano-particles for high-Tc SQUID bio application

S. Tanaka; C. Toriyabe; Y. Torii; Y. Hatsukade; T. Eki; S. Katsura; N. Ohnishi; J. Wan; S. Yang; Y. Zhang

doi:10.1016/j.physc.2007.04.285

Evaluation of thermo responsive magnetic nano-particles for high-T_c SQUID bio application

S. Tanaka^*, C. Toriyabe, Y. Torii, Y. Hatsukade, T. Eki, S. Katsura, N. Ohnishi, J. Wan, S. Yang, Y. Zhang

^*Corresponding author for this work

Undergraduate Program of Electro-Optical Engineering

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Immunoassay or detection of biological molecules using a high sensitive SQUID and magnetic nano-particles as labeling has been recently proposed. In this method, mostly a few particles are labeled on an antibody or biological molecules. If it is possible to give much more magnetic particles to the antibody, sensitivity must notably increase. We propose the use of thermo responsive magnetic nano-particles, which can agglutinate and disperse by themselves associated with temperature. As a preliminary experiment, we investigated the properties of thermo responsive nano-particles made of Fe₃O₄. By detailed study on the particles using an analyzer for a distribution of particle's outer dimension in aqueous liquid, it was found that the dimension increased with temperature above 25°, and became 400 nm at 30.5°. Magnetic measurements of the particles at different conditions using high-T_c SQUID have been done. The results suggested that the particles must be dried by heat before magnetic measurement to enhance the signal from the particles.

Original language	English
Pages (from-to)	1029-1033
Number of pages	5
Journal	Physica C: Superconductivity and its applications
Volume	463-465
Issue number	SUPPL.
DOIs	https://doi.org/10.1016/j.physc.2007.04.285
Publication status	Published - 2007 Oct 1

Keywords

FeO
Immunoassay
Particle
SQUID

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Energy Engineering and Power Technology
Electrical and Electronic Engineering

Access to Document

10.1016/j.physc.2007.04.285

Cite this

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title = "Evaluation of thermo responsive magnetic nano-particles for high-Tc SQUID bio application",

abstract = "Immunoassay or detection of biological molecules using a high sensitive SQUID and magnetic nano-particles as labeling has been recently proposed. In this method, mostly a few particles are labeled on an antibody or biological molecules. If it is possible to give much more magnetic particles to the antibody, sensitivity must notably increase. We propose the use of thermo responsive magnetic nano-particles, which can agglutinate and disperse by themselves associated with temperature. As a preliminary experiment, we investigated the properties of thermo responsive nano-particles made of Fe3O4. By detailed study on the particles using an analyzer for a distribution of particle's outer dimension in aqueous liquid, it was found that the dimension increased with temperature above 25°, and became 400 nm at 30.5°. Magnetic measurements of the particles at different conditions using high-Tc SQUID have been done. The results suggested that the particles must be dried by heat before magnetic measurement to enhance the signal from the particles.",

keywords = "FeO, Immunoassay, Particle, SQUID",

author = "S. Tanaka and C. Toriyabe and Y. Torii and Y. Hatsukade and T. Eki and S. Katsura and N. Ohnishi and J. Wan and S. Yang and Y. Zhang",

note = "Funding Information: This work was supported in part by a Grant-in-Aid for Science Research (B) from Japan Society for the Promotion of Science, and The 21st Century COE Program “Ecological Engineering for Homeostatic Human Activities” from the ministry of Education, Culture, Sports, Science and Technology.",

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AU - Tanaka, S.

AU - Toriyabe, C.

AU - Torii, Y.

AU - Hatsukade, Y.

AU - Eki, T.

AU - Katsura, S.

AU - Ohnishi, N.

AU - Wan, J.

AU - Yang, S.

AU - Zhang, Y.

N1 - Funding Information: This work was supported in part by a Grant-in-Aid for Science Research (B) from Japan Society for the Promotion of Science, and The 21st Century COE Program “Ecological Engineering for Homeostatic Human Activities” from the ministry of Education, Culture, Sports, Science and Technology.

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Immunoassay or detection of biological molecules using a high sensitive SQUID and magnetic nano-particles as labeling has been recently proposed. In this method, mostly a few particles are labeled on an antibody or biological molecules. If it is possible to give much more magnetic particles to the antibody, sensitivity must notably increase. We propose the use of thermo responsive magnetic nano-particles, which can agglutinate and disperse by themselves associated with temperature. As a preliminary experiment, we investigated the properties of thermo responsive nano-particles made of Fe3O4. By detailed study on the particles using an analyzer for a distribution of particle's outer dimension in aqueous liquid, it was found that the dimension increased with temperature above 25°, and became 400 nm at 30.5°. Magnetic measurements of the particles at different conditions using high-Tc SQUID have been done. The results suggested that the particles must be dried by heat before magnetic measurement to enhance the signal from the particles.

AB - Immunoassay or detection of biological molecules using a high sensitive SQUID and magnetic nano-particles as labeling has been recently proposed. In this method, mostly a few particles are labeled on an antibody or biological molecules. If it is possible to give much more magnetic particles to the antibody, sensitivity must notably increase. We propose the use of thermo responsive magnetic nano-particles, which can agglutinate and disperse by themselves associated with temperature. As a preliminary experiment, we investigated the properties of thermo responsive nano-particles made of Fe3O4. By detailed study on the particles using an analyzer for a distribution of particle's outer dimension in aqueous liquid, it was found that the dimension increased with temperature above 25°, and became 400 nm at 30.5°. Magnetic measurements of the particles at different conditions using high-Tc SQUID have been done. The results suggested that the particles must be dried by heat before magnetic measurement to enhance the signal from the particles.

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