Estimation of heritability for varied indexes of handedness

Yin Ju Lien, Wei J. Chen, Po Chang Hsiao, Hui Chun Tsuang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Inconsistent results of the molecular studies for handedness have been reported. One of the key issues involved could be ways of assessing handedness. The current study aimed to identify the index of handedness better reveal the genetic component, which showed higher heritability. We measured handedness using the Annett's handedness questionnaire. The college students participating in this study filled the questionnaire in the class while their first-degree relatives returned questionnaires one to two weeks later. A total of 1,968 subjects returned their questionnaires, including 640 college students and 1,328 first-degree relatives. Among the 449 college students returning at least one handedness questionnaire for their parents, a total of 449 fathers, 440 mothers, and 425 siblings participated in the study. The index of mixed-handedness (e.g., Degree of Handedness) showed highest heritability (0.67), followed by the Hand Preference Index (0.52), and then the Direction of Handedness (0.39). Using an index of mixed-handedness for future molecular studies was suggested.

Original languageEnglish
Pages (from-to)469-482
Number of pages14
JournalLaterality
Volume20
Issue number4
DOIs
Publication statusPublished - 2015 Jul 4

Fingerprint

Functional Laterality
Students
Handedness
Heritability
Fathers
Siblings
Hand
Parents
Mothers
Surveys and Questionnaires
Questionnaire

Keywords

  • Cerebral lateralization
  • Handedness
  • Heritability
  • Schizophrenia

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychology(all)

Cite this

Estimation of heritability for varied indexes of handedness. / Lien, Yin Ju; Chen, Wei J.; Hsiao, Po Chang; Tsuang, Hui Chun.

In: Laterality, Vol. 20, No. 4, 04.07.2015, p. 469-482.

Research output: Contribution to journalArticle

Lien, Yin Ju ; Chen, Wei J. ; Hsiao, Po Chang ; Tsuang, Hui Chun. / Estimation of heritability for varied indexes of handedness. In: Laterality. 2015 ; Vol. 20, No. 4. pp. 469-482.
@article{1fa9d7b1ba154106bef289fd16c1a30d,
title = "Estimation of heritability for varied indexes of handedness",
abstract = "Inconsistent results of the molecular studies for handedness have been reported. One of the key issues involved could be ways of assessing handedness. The current study aimed to identify the index of handedness better reveal the genetic component, which showed higher heritability. We measured handedness using the Annett's handedness questionnaire. The college students participating in this study filled the questionnaire in the class while their first-degree relatives returned questionnaires one to two weeks later. A total of 1,968 subjects returned their questionnaires, including 640 college students and 1,328 first-degree relatives. Among the 449 college students returning at least one handedness questionnaire for their parents, a total of 449 fathers, 440 mothers, and 425 siblings participated in the study. The index of mixed-handedness (e.g., Degree of Handedness) showed highest heritability (0.67), followed by the Hand Preference Index (0.52), and then the Direction of Handedness (0.39). Using an index of mixed-handedness for future molecular studies was suggested.",
keywords = "Cerebral lateralization, Handedness, Heritability, Schizophrenia",
author = "Lien, {Yin Ju} and Chen, {Wei J.} and Hsiao, {Po Chang} and Tsuang, {Hui Chun}",
year = "2015",
month = "7",
day = "4",
doi = "10.1080/1357650X.2014.1000920",
language = "English",
volume = "20",
pages = "469--482",
journal = "Laterality: Asymmetries of Body, Brain and Cognition",
issn = "1357-650X",
publisher = "Psychology Press Ltd",
number = "4",

}

TY - JOUR

T1 - Estimation of heritability for varied indexes of handedness

AU - Lien, Yin Ju

AU - Chen, Wei J.

AU - Hsiao, Po Chang

AU - Tsuang, Hui Chun

PY - 2015/7/4

Y1 - 2015/7/4

N2 - Inconsistent results of the molecular studies for handedness have been reported. One of the key issues involved could be ways of assessing handedness. The current study aimed to identify the index of handedness better reveal the genetic component, which showed higher heritability. We measured handedness using the Annett's handedness questionnaire. The college students participating in this study filled the questionnaire in the class while their first-degree relatives returned questionnaires one to two weeks later. A total of 1,968 subjects returned their questionnaires, including 640 college students and 1,328 first-degree relatives. Among the 449 college students returning at least one handedness questionnaire for their parents, a total of 449 fathers, 440 mothers, and 425 siblings participated in the study. The index of mixed-handedness (e.g., Degree of Handedness) showed highest heritability (0.67), followed by the Hand Preference Index (0.52), and then the Direction of Handedness (0.39). Using an index of mixed-handedness for future molecular studies was suggested.

AB - Inconsistent results of the molecular studies for handedness have been reported. One of the key issues involved could be ways of assessing handedness. The current study aimed to identify the index of handedness better reveal the genetic component, which showed higher heritability. We measured handedness using the Annett's handedness questionnaire. The college students participating in this study filled the questionnaire in the class while their first-degree relatives returned questionnaires one to two weeks later. A total of 1,968 subjects returned their questionnaires, including 640 college students and 1,328 first-degree relatives. Among the 449 college students returning at least one handedness questionnaire for their parents, a total of 449 fathers, 440 mothers, and 425 siblings participated in the study. The index of mixed-handedness (e.g., Degree of Handedness) showed highest heritability (0.67), followed by the Hand Preference Index (0.52), and then the Direction of Handedness (0.39). Using an index of mixed-handedness for future molecular studies was suggested.

KW - Cerebral lateralization

KW - Handedness

KW - Heritability

KW - Schizophrenia

UR - http://www.scopus.com/inward/record.url?scp=84928589868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84928589868&partnerID=8YFLogxK

U2 - 10.1080/1357650X.2014.1000920

DO - 10.1080/1357650X.2014.1000920

M3 - Article

VL - 20

SP - 469

EP - 482

JO - Laterality: Asymmetries of Body, Brain and Cognition

JF - Laterality: Asymmetries of Body, Brain and Cognition

SN - 1357-650X

IS - 4

ER -