Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang; K. W. Huang; S. H. Liao; H. E. Horng; J. J. Chieh; H. H. Chen; M. J. Chen; K. L. Chen; L. M. Wang

doi:10.1063/1.4774291

Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang^*
, K. W. Huang
, S. H. Liao
, H. E. Horng
, J. J. Chieh
, H. H. Chen
, M. J. Chen
, K. L. Chen
, L. M. Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T₁-weighted contrast imaging in ultra-low magnetic fields.

Original language	English
Article number	013119
Journal	Applied Physics Letters
Volume	102
Issue number	1
DOIs	https://doi.org/10.1063/1.4774291
Publication status	Published - 2013 Jan 7

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.4774291

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title = "Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields",

abstract = "In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.",

author = "Yang, \{H. C.\} and Huang, \{K. W.\} and Liao, \{S. H.\} and Horng, \{H. E.\} and Chieh, \{J. J.\} and Chen, \{H. H.\} and Chen, \{M. J.\} and Chen, \{K. L.\} and Wang, \{L. M.\}",

note = "Funding Information: This work was supported by National Science Council of Taiwan under Grant Nos. NSC101-2120 -M-168-001, NSC100-2120 -M-002-015, NSC100-2112 -M-003-011-MY2, and 99-2112-M-168-001-MY3.",

year = "2013",

month = jan,

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doi = "10.1063/1.4774291",

language = "English",

volume = "102",

journal = "Applied Physics Letters",

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T1 - Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

AU - Yang, H. C.

AU - Huang, K. W.

AU - Liao, S. H.

AU - Horng, H. E.

AU - Chieh, J. J.

AU - Chen, H. H.

AU - Chen, M. J.

AU - Chen, K. L.

AU - Wang, L. M.

N1 - Funding Information: This work was supported by National Science Council of Taiwan under Grant Nos. NSC101-2120 -M-168-001, NSC100-2120 -M-002-015, NSC100-2112 -M-003-011-MY2, and 99-2112-M-168-001-MY3.

PY - 2013/1/7

Y1 - 2013/1/7

N2 - In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.

AB - In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.

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JO - Applied Physics Letters

JF - Applied Physics Letters

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ER -

Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

Abstract

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