Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang; K. W. Huang; S. H. Liao; H. E. Horng; J. J. Chieh; H. H. Chen; M. J. Chen; K. L. Chen; L. M. Wang

doi:10.1063/1.4774291

Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang^*, K. W. Huang, S. H. Liao, H. E. Horng, J. J. Chieh, H. H. Chen, M. J. Chen, K. L. Chen, L. M. Wang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T₁-weighted contrast imaging in ultra-low magnetic fields.

Original language	English
Article number	013119
Journal	Applied Physics Letters
Volume	102
Issue number	1
DOIs	https://doi.org/10.1063/1.4774291
Publication status	Published - 2013 Jan 7

ASJC Scopus subject areas

Physics and Astronomy (miscellaneous)

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10.1063/1.4774291

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title = "Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields",

abstract = "In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.",

author = "Yang, {H. C.} and Huang, {K. W.} and Liao, {S. H.} and Horng, {H. E.} and Chieh, {J. J.} and Chen, {H. H.} and Chen, {M. J.} and Chen, {K. L.} and Wang, {L. M.}",

note = "Funding Information: This work was supported by National Science Council of Taiwan under Grant Nos. NSC101-2120 -M-168-001, NSC100-2120 -M-002-015, NSC100-2112 -M-003-011-MY2, and 99-2112-M-168-001-MY3.",

year = "2013",

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doi = "10.1063/1.4774291",

language = "English",

volume = "102",

journal = "Applied Physics Letters",

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T1 - Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

AU - Yang, H. C.

AU - Huang, K. W.

AU - Liao, S. H.

AU - Horng, H. E.

AU - Chieh, J. J.

AU - Chen, H. H.

AU - Chen, M. J.

AU - Chen, K. L.

AU - Wang, L. M.

N1 - Funding Information: This work was supported by National Science Council of Taiwan under Grant Nos. NSC101-2120 -M-168-001, NSC100-2120 -M-002-015, NSC100-2112 -M-003-011-MY2, and 99-2112-M-168-001-MY3.

PY - 2013/1/7

Y1 - 2013/1/7

N2 - In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.

AB - In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.

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Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

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