Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

Hong-Chang Yang, K. W. Huang, Shu-Hsien Liao, Herng-Er Horng, Jen-Je Chieh, H. H. Chen, M. J. Chen, K. L. Chen, L. M. Wang

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Abstract

    In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.

    Original languageEnglish
    Article number013119
    JournalApplied Physics Letters
    Volume102
    Issue number1
    DOIs
    Publication statusPublished - 2013 Jan 7

    Fingerprint

    antibodies
    discrimination
    tumors
    liver
    nanoparticles
    magnetic fields
    rats
    magnetic resonance
    veins
    injection

    ASJC Scopus subject areas

    • Physics and Astronomy (miscellaneous)

    Cite this

    Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields. / Yang, Hong-Chang; Huang, K. W.; Liao, Shu-Hsien; Horng, Herng-Er; Chieh, Jen-Je; Chen, H. H.; Chen, M. J.; Chen, K. L.; Wang, L. M.

    In: Applied Physics Letters, Vol. 102, No. 1, 013119, 07.01.2013.

    Research output: Contribution to journalArticle

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