Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang, K. W. Huang, S. H. Liao, H. E. Horng, J. J. Chieh, H. H. Chen, M. J. Chen, K. L. Chen, L. M. Wang

    Research output: Contribution to journalArticlepeer-review

    8 Citations (Scopus)

    Abstract

    In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.

    Original languageEnglish
    Article number013119
    JournalApplied Physics Letters
    Volume102
    Issue number1
    DOIs
    Publication statusPublished - 2013 Jan 7

    ASJC Scopus subject areas

    • Physics and Astronomy (miscellaneous)

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