Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang, K. W. Huang, S. H. Liao, H. E. Horng, J. J. Chieh, H. H. Chen, M. J. Chen, K. L. Chen, L. M. Wang

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In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.

Original languageEnglish
Article number013119
JournalApplied Physics Letters
Issue number1
Publication statusPublished - 2013 Jan 7


ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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