Enhancing the tumor discrimination using antibody-activated magnetic nanoparticles in ultra-low magnetic fields

H. C. Yang, K. W. Huang, S. H. Liao, H. E. Horng, J. J. Chieh, H. H. Chen, M. J. Chen, K. L. Chen, L. M. Wang

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

In this paper, we report an enhanced liver tumor discrimination for rats using antibody-activated magnetic nanoparticles (MNs) and ultra-low-field magnetic resonance imaging ex vivo. It was found that the intensity ratio between the magnetic resonance image of tumor and normal liver tissues is 2-3 absence of antibody-activated MNs in rats. The intensity ratio rises to ∼100 when antibody-activated MNs are expressed in liver tumors through vein injection. Enhancing tumor discrimination using antibody-activated MNs is demonstrated using T1-weighted contrast imaging in ultra-low magnetic fields.

Original languageEnglish
Article number013119
JournalApplied Physics Letters
Volume102
Issue number1
DOIs
Publication statusPublished - 2013 Jan 7

ASJC Scopus subject areas

  • Physics and Astronomy (miscellaneous)

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