Encephalitis in Taiwan: A prospective hospital-based study

Tzu Chi Lee, Ching Piao Tsai*, Chih Lun Yuan, Cheng Yu Wei, Wen Long Tsao, Rung Jan Lee, Su Yi Cheih, I. Tsong Huang, Kow Tong Chen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)


To investigate encephalitis in Taiwan, a multicenter study was conducted with patients who had acute severe neurological dysfunction and suspected encephalitis from May 2000 to December 2001. Demographic data such as age, sex, and seasons were analyzed. Polymerase chain reaction analyses were performed to determine the microbiologic diagnosis. The patients included 73 males and 54 females, with a peak age of 10-40 years old. Microbiologic diagnoses in 86 (69%) of 124 cases involved herpes simplex virus (HSV, 45 cases), varicella zoster (16 cases), Mycobacterium tuberculosis (10 cases), cytomegalovirus (8 cases), adenovirus (5 cases), influenza (1 case), and enterovirus (1 case). Pathogens were found in 69% of the cases. Encephalitis was most likely to occur in June and July. Based on the results, HSV is still the major viral cause of encephalitis in Taiwan.

Original languageEnglish
Pages (from-to)193-199
Number of pages7
JournalJapanese Journal of Infectious Diseases
Issue number5-6
Publication statusPublished - 2003 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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