Enantioselective synthesis of substituted pyrans via amine-catalyzed Michael addition and subsequent enolization/cyclisation

Utpal Das, Chan Hui Huang, Wenwei Lin

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

An organocatalytic construction of optically enriched substituted pyran derivatives via amine-catalyzed Michael addition and subsequent enolization/cyclisation has been described starting from electronically poor alkenes. Functionalized pyrans were obtained in high enantioselectivities (up to 96%) and good yields (up to 90%) having three contiguous chiral centers.

Original languageEnglish
Pages (from-to)5590-5592
Number of pages3
JournalChemical Communications
Volume48
Issue number45
DOIs
Publication statusPublished - 2012 May 9

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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