Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C-Aliphatic Homoallylic Amines

Wei Sian Li, Ting Shen Kuo, Meng Chi Hsieh, Ming Kang Tsai, Ping Yu Wu, Hsyueh Liang Wu

    Research output: Contribution to journalArticlepeer-review

    1 Citation (Scopus)

    Abstract

    Reported herein is a method for the efficient syntheses of optically active 1-alkyl homoallylic amines in yields up to 95%, 13.5:1 dr, and 98% ee under mild, aqueous reaction conditions, via the Rh-catalyzed asymmetric allylation of aliphatic aldimines. This method provides a streamlined synthetic platform for the preparation of indolizidine and piperidine alkaloids, thus demonstrating its usefulness.

    Original languageEnglish
    Pages (from-to)5675-5679
    Number of pages5
    JournalOrganic Letters
    Volume22
    Issue number14
    DOIs
    Publication statusPublished - 2020 Jul 17

    ASJC Scopus subject areas

    • Biochemistry
    • Physical and Theoretical Chemistry
    • Organic Chemistry

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