Abstract
Reported herein is a method for the efficient syntheses of optically active 1-alkyl homoallylic amines in yields up to 95%, 13.5:1 dr, and 98% ee under mild, aqueous reaction conditions, via the Rh-catalyzed asymmetric allylation of aliphatic aldimines. This method provides a streamlined synthetic platform for the preparation of indolizidine and piperidine alkaloids, thus demonstrating its usefulness.
| Original language | English |
|---|---|
| Pages (from-to) | 5675-5679 |
| Number of pages | 5 |
| Journal | Organic Letters |
| Volume | 22 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 2020 Jul 17 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Li, W. S., Kuo, T. S., Hsieh, M. C., Tsai, M. K., Wu, P. Y., & Wu, H. L. (2020). Enantioselective Rhodium-Catalyzed Allylation of Aliphatic Imines: Synthesis of Chiral C-Aliphatic Homoallylic Amines. Organic Letters, 22(14), 5675-5679. https://doi.org/10.1021/acs.orglett.0c02069