Abstract
Reported herein is a method for the efficient syntheses of optically active 1-alkyl homoallylic amines in yields up to 95%, 13.5:1 dr, and 98% ee under mild, aqueous reaction conditions, via the Rh-catalyzed asymmetric allylation of aliphatic aldimines. This method provides a streamlined synthetic platform for the preparation of indolizidine and piperidine alkaloids, thus demonstrating its usefulness.
Original language | English |
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Pages (from-to) | 5675-5679 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 22 |
Issue number | 14 |
DOIs | |
Publication status | Published - 2020 Jul 17 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry