Enantioselective addition of dialkylzincs to aldehydes catalyzed by (-)-MITH

Ying Ni Cheng, Hsyueh Liang Wu, Ping Yu Wu, Ying Ying Shen, Biing Jiun Uang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

An effective catalytic system that imparts high enantioselectivity has been disclosed for the synthesis of optically active alcohols, which may undergo further chemical transformations. The enantioselective alkylation of aldehydes with dialkylzincs to afford the corresponding optically active alcohols with excellent enantioselectvities has been achieved in the presence of 0.1-0.5 mol % of the camphor-derived chiral ligand (-)-2-exo-morpholinoisobornane-10-thiol (MITH) (1) at room temperature or at 0 °C. I zinc so too: The enantioselective alkylation of aldehydes with dialkylzincs yielded the desired alcohol products with up to 99 % ee in the presence of 0.1-0.5 mol % of ligand (-)-2-exo-morpholinoisoborne-10-thiol (1) at room temperature or at 0°C.

Original languageEnglish
Pages (from-to)2921-2924
Number of pages4
JournalChemistry - An Asian Journal
Volume7
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1

Keywords

  • alcohols
  • aldehydes
  • enantioselective addition
  • homogeneous catalysis
  • organozincs

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry

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