Electrospun scaffolds composing of alginate, chitosan, collagen and hydroxyapatite for applying in bone tissue engineering

Chia Cherng Yu, Jung Jhih Chang, Yen Hsien Lee, Yu Cheng Lin, Meng Hsiu Wu, Ming Chien Yang, Chiang Ting Chien

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61 Citations (Scopus)


In this study, a composite scaffold made of alginate (AL), chitosan (ChS), collagen (Col), and hydroxyapatite (HAp) was fabricated by electrospinning techniques. The distribution of each component of composite scaffold was revealed by confocal laser scanning microscope (CLSM) using fluorescent labeling polymers. The morphology and microstructure of the scaffold was examined using a field-emission scanning electron microscope (FE-SEM) and transmission electron microscopy (TEM). To mimic the stability of these scaffolds in physiological fluids, the degree of disintegration of collagen from these scaffolds in collagenase solution was also tested. The results showed that the composite scaffold can greatly reduce the disintegration by 35% for 10 days in collagenase solution. Therefore, this composite is expected to be a potential scaffold for bone tissue engineering applications.

Original languageEnglish
Pages (from-to)133-136
Number of pages4
JournalMaterials Letters
Publication statusPublished - 2013 Jan 7



  • Biomimetic
  • Collagen
  • Electrospinning
  • Hydroxyapatite
  • Polymeric composites

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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