Electrospun anti-adhesion barrier made of chitosan alginate for reducing peritoneal adhesions

Jung Jhih Chang; Yen Hsien Lee; Meng Hsiu Wu; Ming Chien Yang; Chiang Ting Chien

doi:10.1016/j.carbpol.2012.02.011

Electrospun anti-adhesion barrier made of chitosan alginate for reducing peritoneal adhesions

Jung Jhih Chang, Yen Hsien Lee, Meng Hsiu Wu, Ming Chien Yang^*, Chiang Ting Chien

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

64 Citations (Scopus)

Abstract

In this study, novel anti-adhesion mat made of chitosan alginate was fabricated via electrospinning. The structure and morphology of electrospun membrane were examined using a field-emission scanning electron microscope and confocal laser scanning microscope. The degree of disintegration of the electrospun mat was assessed. The results showed that the degree of disintegration in DMEM for chitosan alginate mat was 64% of that of conventional calcium alginate mat after 5 days. In addition, the tissue anti-adhesion potential was evaluated with in vitro cell adhesion model and in vivo rat model. About 40% of the animals treated with chitosan alginate exhibited no tissue adhesion between injured peritoneum and cecum. The result demonstrated that chitosan alginate was effective in reducing the formation of tissue adhesion.

Original language	English
Pages (from-to)	1304-1312
Number of pages	9
Journal	Carbohydrate Polymers
Volume	88
Issue number	4
DOIs	https://doi.org/10.1016/j.carbpol.2012.02.011
Publication status	Published - 2012 May 16
Externally published	Yes

Keywords

Animal model
Anti-adhesion
Chitosan
Electrospun mats
Sodium alginate

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2012.02.011

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title = "Electrospun anti-adhesion barrier made of chitosan alginate for reducing peritoneal adhesions",

abstract = "In this study, novel anti-adhesion mat made of chitosan alginate was fabricated via electrospinning. The structure and morphology of electrospun membrane were examined using a field-emission scanning electron microscope and confocal laser scanning microscope. The degree of disintegration of the electrospun mat was assessed. The results showed that the degree of disintegration in DMEM for chitosan alginate mat was 64% of that of conventional calcium alginate mat after 5 days. In addition, the tissue anti-adhesion potential was evaluated with in vitro cell adhesion model and in vivo rat model. About 40% of the animals treated with chitosan alginate exhibited no tissue adhesion between injured peritoneum and cecum. The result demonstrated that chitosan alginate was effective in reducing the formation of tissue adhesion.",

keywords = "Animal model, Anti-adhesion, Chitosan, Electrospun mats, Sodium alginate",

author = "Chang, {Jung Jhih} and Lee, {Yen Hsien} and Wu, {Meng Hsiu} and Yang, {Ming Chien} and Chien, {Chiang Ting}",

note = "Funding Information: The authors would like to thank the National Science Council of Taiwan, Republic of China , for financially supporting this research under Grants NSC-100-2120-M-038-022 , and NSC-98-2320-B-002-043-MY3 . The authors would also like to thank National Taiwan University Hospital for providing Grant NTUH 100-S1661 .",

year = "2012",

month = may,

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doi = "10.1016/j.carbpol.2012.02.011",

language = "English",

volume = "88",

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T1 - Electrospun anti-adhesion barrier made of chitosan alginate for reducing peritoneal adhesions

AU - Chang, Jung Jhih

AU - Lee, Yen Hsien

AU - Wu, Meng Hsiu

AU - Yang, Ming Chien

AU - Chien, Chiang Ting

N1 - Funding Information: The authors would like to thank the National Science Council of Taiwan, Republic of China , for financially supporting this research under Grants NSC-100-2120-M-038-022 , and NSC-98-2320-B-002-043-MY3 . The authors would also like to thank National Taiwan University Hospital for providing Grant NTUH 100-S1661 .

PY - 2012/5/16

Y1 - 2012/5/16

N2 - In this study, novel anti-adhesion mat made of chitosan alginate was fabricated via electrospinning. The structure and morphology of electrospun membrane were examined using a field-emission scanning electron microscope and confocal laser scanning microscope. The degree of disintegration of the electrospun mat was assessed. The results showed that the degree of disintegration in DMEM for chitosan alginate mat was 64% of that of conventional calcium alginate mat after 5 days. In addition, the tissue anti-adhesion potential was evaluated with in vitro cell adhesion model and in vivo rat model. About 40% of the animals treated with chitosan alginate exhibited no tissue adhesion between injured peritoneum and cecum. The result demonstrated that chitosan alginate was effective in reducing the formation of tissue adhesion.

AB - In this study, novel anti-adhesion mat made of chitosan alginate was fabricated via electrospinning. The structure and morphology of electrospun membrane were examined using a field-emission scanning electron microscope and confocal laser scanning microscope. The degree of disintegration of the electrospun mat was assessed. The results showed that the degree of disintegration in DMEM for chitosan alginate mat was 64% of that of conventional calcium alginate mat after 5 days. In addition, the tissue anti-adhesion potential was evaluated with in vitro cell adhesion model and in vivo rat model. About 40% of the animals treated with chitosan alginate exhibited no tissue adhesion between injured peritoneum and cecum. The result demonstrated that chitosan alginate was effective in reducing the formation of tissue adhesion.

KW - Animal model

KW - Anti-adhesion

KW - Chitosan

KW - Electrospun mats

KW - Sodium alginate

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Electrospun anti-adhesion barrier made of chitosan alginate for reducing peritoneal adhesions

Abstract

Keywords

ASJC Scopus subject areas

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