Efficient TCT-catalyzed synthesis of 1,5-benzodiazepine derivatives under mild conditions

Chun Wei Kuo; Chun Chao Wang; Veerababurao Kavala; Ching Fa Yao

doi:10.3390/molecules13092313

Efficient TCT-catalyzed synthesis of 1,5-benzodiazepine derivatives under mild conditions

Chun Wei Kuo, Chun Chao Wang, Veerababurao Kavala, Ching Fa Yao^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

39 Citations (Scopus)

Abstract

2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.

Original language	English
Pages (from-to)	2313-2325
Number of pages	13
Journal	Molecules
Volume	13
Issue number	9
DOIs	https://doi.org/10.3390/molecules13092313
Publication status	Published - 2008 Sept

Keywords

2,4,6-trichloro-1,3,5-triazine
Benzodiazepines
Enolizable ketones
O-phenylenediamines

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules13092313

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abstract = "2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.",

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author = "Kuo, {Chun Wei} and Wang, {Chun Chao} and Veerababurao Kavala and Yao, {Ching Fa}",

year = "2008",

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T1 - Efficient TCT-catalyzed synthesis of 1,5-benzodiazepine derivatives under mild conditions

AU - Kuo, Chun Wei

AU - Wang, Chun Chao

AU - Kavala, Veerababurao

AU - Yao, Ching Fa

PY - 2008/9

Y1 - 2008/9

N2 - 2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.

AB - 2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.

KW - 2,4,6-trichloro-1,3,5-triazine

KW - Benzodiazepines

KW - Enolizable ketones

KW - O-phenylenediamines

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JO - Molecules

JF - Molecules

IS - 9

ER -

Efficient TCT-catalyzed synthesis of 1,5-benzodiazepine derivatives under mild conditions

Abstract

Keywords

ASJC Scopus subject areas

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