Efficient TCT-catalyzed synthesis of 1,5-benzodiazepine derivatives under mild conditions

Chun Wei Kuo, Chun Chao Wang, Veerababurao Kavala, Ching Fa Yao

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

2,4,6-Trichloro-1,3,5-triazine (TCT) efficiently catalyzed the condensation reactions between 1,2-diamines and various enolizable ketones to afford 1,5-benzodiazepines in good to excellent yields. Simple and mild reaction conditions, the use of a cheap catalyst and easy workup and isolation are notable features of this method.

Original languageEnglish
Pages (from-to)2313-2325
Number of pages13
JournalMolecules
Volume13
Issue number9
DOIs
Publication statusPublished - 2008 Sep 1

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Keywords

  • 2,4,6-trichloro-1,3,5-triazine
  • Benzodiazepines
  • Enolizable ketones
  • O-phenylenediamines

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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