Effects of caffeic acid and cinnamic acid on glucose uptake in insulin-resistant mouse hepatocytes

D. A.Wei Huang, Szu Chuan Shen, James Swi-Bea Wu*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)

Abstract

Tumor necrosis factor-a was used to induce insulin resistance of mouse liver FL83B cells. Two phenolic acids, caffeic acid and cinnamic acid, were then added separately to investigate their effects on glucose uptake of the insulin-resistant cells. The results suggest that these two phenolic acids may promote insulin receptor tyrosyl phosphorylation, up-regulate the expression of insulin signal associated proteins, including insulin receptor, phosphatidylinositol-3 kinase, glycogen synthase, and glucose transporter-2, increase the uptake of glucose, and alleviate insulin resistance in cells as a consequence.

Original languageEnglish
Pages (from-to)7687-7692
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume57
Issue number17
DOIs
Publication statusPublished - 2009 Sept 9
Externally publishedYes

Keywords

  • Caffeic acid
  • Cinnamic acid
  • Diabetes mellitus
  • Glucose uptake
  • Insulin resistance

ASJC Scopus subject areas

  • General Chemistry
  • General Agricultural and Biological Sciences

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