Effects of atrial natriuretic factor in chronic hypoxic spontaneously hypertensive rats

C. F. Chen, C. T. Chien, H. S. Fang, I. S. Chiu

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

The present study was designed first to investigate the pulmonary hypertensive effects of chronic hypoxia in spontaneously hypertensive rats and second to compare the cardiovascular effects of atrial natriuretic factor on rats exposed to hypoxia and on control rats kept at sea level. Catheters were placed in the femoral and pulmonary arteries for measurement of mean systemic arterial pressure and mean pulmonary arterial pressure. The cardiac output was measured by thermodilution method. It was found that 4 weeks of simulated 18,000-foot hypoxia led to polycythemia, right ventricular hypertrophy, and pulmonary hypertension, which resulted from an increased pulmonary vascular resistance. However, systemic arterial pressure was not significantly different between the two groups of rats. Atrial natriuretic factor administration decreased systemic arterial pressure and pulmonary arterial pressure to a lesser extent in the hypoxic group compared with the sea level control group. It is concluded that these animals showed an impaired response to atrial natriuretic factor after long-term exposure to hypoxia.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
JournalHypertension
Volume18
Issue number3
DOIs
Publication statusPublished - 1991 Jan 1

Fingerprint

Atrial Natriuretic Factor
Inbred SHR Rats
Arterial Pressure
Oceans and Seas
Lung
Right Ventricular Hypertrophy
Thermodilution
Polycythemia
Femoral Artery
Pulmonary Hypertension
Cardiac Output
Vascular Resistance
Pulmonary Artery
Catheters
Control Groups
Hypoxia

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Effects of atrial natriuretic factor in chronic hypoxic spontaneously hypertensive rats. / Chen, C. F.; Chien, C. T.; Fang, H. S.; Chiu, I. S.

In: Hypertension, Vol. 18, No. 3, 01.01.1991, p. 355-359.

Research output: Contribution to journalArticle

Chen, C. F. ; Chien, C. T. ; Fang, H. S. ; Chiu, I. S. / Effects of atrial natriuretic factor in chronic hypoxic spontaneously hypertensive rats. In: Hypertension. 1991 ; Vol. 18, No. 3. pp. 355-359.
@article{fd167e2041ab4bd98087f0babb278911,
title = "Effects of atrial natriuretic factor in chronic hypoxic spontaneously hypertensive rats",
abstract = "The present study was designed first to investigate the pulmonary hypertensive effects of chronic hypoxia in spontaneously hypertensive rats and second to compare the cardiovascular effects of atrial natriuretic factor on rats exposed to hypoxia and on control rats kept at sea level. Catheters were placed in the femoral and pulmonary arteries for measurement of mean systemic arterial pressure and mean pulmonary arterial pressure. The cardiac output was measured by thermodilution method. It was found that 4 weeks of simulated 18,000-foot hypoxia led to polycythemia, right ventricular hypertrophy, and pulmonary hypertension, which resulted from an increased pulmonary vascular resistance. However, systemic arterial pressure was not significantly different between the two groups of rats. Atrial natriuretic factor administration decreased systemic arterial pressure and pulmonary arterial pressure to a lesser extent in the hypoxic group compared with the sea level control group. It is concluded that these animals showed an impaired response to atrial natriuretic factor after long-term exposure to hypoxia.",
author = "Chen, {C. F.} and Chien, {C. T.} and Fang, {H. S.} and Chiu, {I. S.}",
year = "1991",
month = "1",
day = "1",
doi = "10.1161/01.HYP.18.3.355",
language = "English",
volume = "18",
pages = "355--359",
journal = "Hypertension",
issn = "0194-911X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Effects of atrial natriuretic factor in chronic hypoxic spontaneously hypertensive rats

AU - Chen, C. F.

AU - Chien, C. T.

AU - Fang, H. S.

AU - Chiu, I. S.

PY - 1991/1/1

Y1 - 1991/1/1

N2 - The present study was designed first to investigate the pulmonary hypertensive effects of chronic hypoxia in spontaneously hypertensive rats and second to compare the cardiovascular effects of atrial natriuretic factor on rats exposed to hypoxia and on control rats kept at sea level. Catheters were placed in the femoral and pulmonary arteries for measurement of mean systemic arterial pressure and mean pulmonary arterial pressure. The cardiac output was measured by thermodilution method. It was found that 4 weeks of simulated 18,000-foot hypoxia led to polycythemia, right ventricular hypertrophy, and pulmonary hypertension, which resulted from an increased pulmonary vascular resistance. However, systemic arterial pressure was not significantly different between the two groups of rats. Atrial natriuretic factor administration decreased systemic arterial pressure and pulmonary arterial pressure to a lesser extent in the hypoxic group compared with the sea level control group. It is concluded that these animals showed an impaired response to atrial natriuretic factor after long-term exposure to hypoxia.

AB - The present study was designed first to investigate the pulmonary hypertensive effects of chronic hypoxia in spontaneously hypertensive rats and second to compare the cardiovascular effects of atrial natriuretic factor on rats exposed to hypoxia and on control rats kept at sea level. Catheters were placed in the femoral and pulmonary arteries for measurement of mean systemic arterial pressure and mean pulmonary arterial pressure. The cardiac output was measured by thermodilution method. It was found that 4 weeks of simulated 18,000-foot hypoxia led to polycythemia, right ventricular hypertrophy, and pulmonary hypertension, which resulted from an increased pulmonary vascular resistance. However, systemic arterial pressure was not significantly different between the two groups of rats. Atrial natriuretic factor administration decreased systemic arterial pressure and pulmonary arterial pressure to a lesser extent in the hypoxic group compared with the sea level control group. It is concluded that these animals showed an impaired response to atrial natriuretic factor after long-term exposure to hypoxia.

UR - http://www.scopus.com/inward/record.url?scp=0025785231&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025785231&partnerID=8YFLogxK

U2 - 10.1161/01.HYP.18.3.355

DO - 10.1161/01.HYP.18.3.355

M3 - Article

C2 - 1832412

AN - SCOPUS:0025785231

VL - 18

SP - 355

EP - 359

JO - Hypertension

JF - Hypertension

SN - 0194-911X

IS - 3

ER -