TY - JOUR
T1 - Effect of resistance exercise on muscle steroid receptor protein content in strength-trained men and women
AU - Vingren, Jakob L.
AU - Kraemer, William J.
AU - Hatfield, Disa L.
AU - Volek, Jeff S.
AU - Ratamess, Nicholas A.
AU - Anderson, Jeffrey M.
AU - Häkkinen, Keijo
AU - Ahtiainen, Juha
AU - Fragala, Maren S.
AU - Thomas, Gwendolyn A.
AU - Ho, Jen Yu
AU - Maresh, Carl M.
PY - 2009/11
Y1 - 2009/11
N2 - The purpose of this study was to examine the acute effect of resistance exercise (RE) on muscle androgen receptor (AR) and glucocorticoid receptor (GR) protein content. Fifteen resistance-trained men (n = 8; 21 ± 1 years, 175.3 ± 6.7 cm, 90.8 ± 11.6 kg) and women (n = 7; 24 ± 5 years, 164.6 ± 6.7 cm, 76.4 ± 15.6 kg) completed 6 sets of 10 repetitions of heavy squats. Blood samples were obtained before RE, after 3 and 6 sets of squats, and 5, 15, 30 and 70 min after RE. Muscle biopsies from the vastus lateralis were obtained before RE, and 10 min and 70 min after RE. Blood samples were analyzed for total and free testosterone concentrations and muscle samples were analyzed for AR and GR protein content. Circulating total testosterone increased significantly (p ≤ 0.05) in men and free testosterone increased in men and women with exercise. AR was significantly reduced at 70 min post-exercise in men and at 10 min post-exercise in women compared to pre-exercise. There were no changes in GR following RE, but GR was significantly higher in women compared to men. These findings support a current paradigm for stabilization followed by a reduction and then a rebound in the acute AR response to RE but demonstrate that gender differences exist in the timeline of the AR response.
AB - The purpose of this study was to examine the acute effect of resistance exercise (RE) on muscle androgen receptor (AR) and glucocorticoid receptor (GR) protein content. Fifteen resistance-trained men (n = 8; 21 ± 1 years, 175.3 ± 6.7 cm, 90.8 ± 11.6 kg) and women (n = 7; 24 ± 5 years, 164.6 ± 6.7 cm, 76.4 ± 15.6 kg) completed 6 sets of 10 repetitions of heavy squats. Blood samples were obtained before RE, after 3 and 6 sets of squats, and 5, 15, 30 and 70 min after RE. Muscle biopsies from the vastus lateralis were obtained before RE, and 10 min and 70 min after RE. Blood samples were analyzed for total and free testosterone concentrations and muscle samples were analyzed for AR and GR protein content. Circulating total testosterone increased significantly (p ≤ 0.05) in men and free testosterone increased in men and women with exercise. AR was significantly reduced at 70 min post-exercise in men and at 10 min post-exercise in women compared to pre-exercise. There were no changes in GR following RE, but GR was significantly higher in women compared to men. These findings support a current paradigm for stabilization followed by a reduction and then a rebound in the acute AR response to RE but demonstrate that gender differences exist in the timeline of the AR response.
KW - Androgen receptor
KW - Endocrine
KW - Exercise training
KW - Glucocorticoid receptor
KW - Testosterone
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U2 - 10.1016/j.steroids.2009.08.002
DO - 10.1016/j.steroids.2009.08.002
M3 - Article
C2 - 19683543
AN - SCOPUS:70350572436
SN - 0039-128X
VL - 74
SP - 1033
EP - 1039
JO - Steroids
JF - Steroids
IS - 13-14
ER -