Effect of molecule-particle binding on the reduction in the mixed-frequency alternating current magnetic susceptibility of magnetic bio-reagents

C. C. Yang; S. Y. Yang; H. H. Chen; W. L. Weng; H. E. Horng; J. J. Chieh; C. Y. Hong; H. C. Yang

doi:10.1063/1.4739735

Effect of molecule-particle binding on the reduction in the mixed-frequency alternating current magnetic susceptibility of magnetic bio-reagents

C. C. Yang, S. Y. Yang, H. H. Chen, W. L. Weng, H. E. Horng^*, J. J. Chieh, C. Y. Hong, H. C. Yang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

By specifically bio-functionalizing magnetic nanoparticles, magnetic nanoparticles are able to label target bio-molecules. This property can be applied to quantitatively detect molecules invitro by measuring the related magnetic signals of nanoparticles bound with target molecules. One of the magnetic signals is the reduction in the mixed-frequency ac magnetic susceptibility of suspended magnetic nanoparticles due to the molecule-particle association. Many experimental results show empirically that the molecular-concentration dependent reduction in ac magnetic susceptibility follows the logistic function. In this study, it has been demonstrated that the logistic behavior is originated from the growth of particle sizes due to the molecule-particle association. The analytic relationship between the growth of particle sizes and the reduction in ac magnetic susceptibility is developed.

Original language	English
Article number	024704
Journal	Journal of Applied Physics
Volume	112
Issue number	2
DOIs	https://doi.org/10.1063/1.4739735
Publication status	Published - 2012 Jul 15

ASJC Scopus subject areas

General Physics and Astronomy

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@article{8da23b28bc694b32947ebb1fb52086d6,

title = "Effect of molecule-particle binding on the reduction in the mixed-frequency alternating current magnetic susceptibility of magnetic bio-reagents",

abstract = "By specifically bio-functionalizing magnetic nanoparticles, magnetic nanoparticles are able to label target bio-molecules. This property can be applied to quantitatively detect molecules invitro by measuring the related magnetic signals of nanoparticles bound with target molecules. One of the magnetic signals is the reduction in the mixed-frequency ac magnetic susceptibility of suspended magnetic nanoparticles due to the molecule-particle association. Many experimental results show empirically that the molecular-concentration dependent reduction in ac magnetic susceptibility follows the logistic function. In this study, it has been demonstrated that the logistic behavior is originated from the growth of particle sizes due to the molecule-particle association. The analytic relationship between the growth of particle sizes and the reduction in ac magnetic susceptibility is developed.",

author = "Yang, {C. C.} and Yang, {S. Y.} and Chen, {H. H.} and Weng, {W. L.} and Horng, {H. E.} and Chieh, {J. J.} and Hong, {C. Y.} and Yang, {H. C.}",

note = "Funding Information: This work was supported by the National Science Council of Taiwan under Grant Nos. 98-2112-M-003-003, 98-2323-B-003-001-CC2, NSC98-2752-M-002-016-PAE, and NSC 100-2120-M-002-015, the Department of Health under grant number DOH99-TD-N-111-008 and DOH100-TD-N-111-008, and the Ministry of Economic Affairs of Taiwan under grant numbers 1Z970688, 1Z0990415 (SBIR), and S09800226-203 (JAID).",

year = "2012",

month = jul,

day = "15",

doi = "10.1063/1.4739735",

language = "English",

volume = "112",

journal = "Journal of Applied Physics",

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T1 - Effect of molecule-particle binding on the reduction in the mixed-frequency alternating current magnetic susceptibility of magnetic bio-reagents

AU - Yang, C. C.

AU - Yang, S. Y.

AU - Chen, H. H.

AU - Weng, W. L.

AU - Horng, H. E.

AU - Chieh, J. J.

AU - Hong, C. Y.

AU - Yang, H. C.

N1 - Funding Information: This work was supported by the National Science Council of Taiwan under Grant Nos. 98-2112-M-003-003, 98-2323-B-003-001-CC2, NSC98-2752-M-002-016-PAE, and NSC 100-2120-M-002-015, the Department of Health under grant number DOH99-TD-N-111-008 and DOH100-TD-N-111-008, and the Ministry of Economic Affairs of Taiwan under grant numbers 1Z970688, 1Z0990415 (SBIR), and S09800226-203 (JAID).

PY - 2012/7/15

Y1 - 2012/7/15

N2 - By specifically bio-functionalizing magnetic nanoparticles, magnetic nanoparticles are able to label target bio-molecules. This property can be applied to quantitatively detect molecules invitro by measuring the related magnetic signals of nanoparticles bound with target molecules. One of the magnetic signals is the reduction in the mixed-frequency ac magnetic susceptibility of suspended magnetic nanoparticles due to the molecule-particle association. Many experimental results show empirically that the molecular-concentration dependent reduction in ac magnetic susceptibility follows the logistic function. In this study, it has been demonstrated that the logistic behavior is originated from the growth of particle sizes due to the molecule-particle association. The analytic relationship between the growth of particle sizes and the reduction in ac magnetic susceptibility is developed.

AB - By specifically bio-functionalizing magnetic nanoparticles, magnetic nanoparticles are able to label target bio-molecules. This property can be applied to quantitatively detect molecules invitro by measuring the related magnetic signals of nanoparticles bound with target molecules. One of the magnetic signals is the reduction in the mixed-frequency ac magnetic susceptibility of suspended magnetic nanoparticles due to the molecule-particle association. Many experimental results show empirically that the molecular-concentration dependent reduction in ac magnetic susceptibility follows the logistic function. In this study, it has been demonstrated that the logistic behavior is originated from the growth of particle sizes due to the molecule-particle association. The analytic relationship between the growth of particle sizes and the reduction in ac magnetic susceptibility is developed.

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Effect of molecule-particle binding on the reduction in the mixed-frequency alternating current magnetic susceptibility of magnetic bio-reagents

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