Effect of molecule-particle binding on the reduction in the mixed-frequency alternating current magnetic susceptibility of magnetic bio-reagents

C. C. Yang, S. Y. Yang, H. H. Chen, W. L. Weng, H. E. Horng, J. J. Chieh, C. Y. Hong, H. C. Yang

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

By specifically bio-functionalizing magnetic nanoparticles, magnetic nanoparticles are able to label target bio-molecules. This property can be applied to quantitatively detect molecules invitro by measuring the related magnetic signals of nanoparticles bound with target molecules. One of the magnetic signals is the reduction in the mixed-frequency ac magnetic susceptibility of suspended magnetic nanoparticles due to the molecule-particle association. Many experimental results show empirically that the molecular-concentration dependent reduction in ac magnetic susceptibility follows the logistic function. In this study, it has been demonstrated that the logistic behavior is originated from the growth of particle sizes due to the molecule-particle association. The analytic relationship between the growth of particle sizes and the reduction in ac magnetic susceptibility is developed.

Original languageEnglish
Article number024704
JournalJournal of Applied Physics
Volume112
Issue number2
DOIs
Publication statusPublished - 2012 Jul 15

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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