Effect of guava (psidium guajava linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats

Szu-Chuan Shen, Fang Chi Cheng, Ning Jung Wu

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

This study investigated the effect of aqueous and ethanol soluble solid extracts of guava (Psidium guajava Linn.) leaves on hypoglycemia and glucose metabolism in type 2 diabetic rats. Low-dose streptozotocin (STZ) and nicotinamide were injected into Sprague-Dawley (SD) rats to induce type 2 diabetes. Acute and long-term feeding tests were carried out, and an oral glucose tolerance test (OGTT) to follow the changes in plasma glucose and insulin levels was performed to evaluate the antihyperglycemic effect of guava leaf extracts in diabetic rats. The results of acute and long-term feeding tests showed a significant reduction in the blood sugar level in diabetic rats fed with either the aqueous or ethanol extract of guava leaves (p < 0.05). Long-term administration of guava leaf extracts increased the plasma insulin level and glucose utilization in diabetic rats. The results also indicated that the activities of hepatic hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase in diabetic rats fed with aqueous extracts were higher than in the normal diabetic group (p < 0.05). On the other hand, diabetic rats treated with the ethanol extract raised the activities of hepatic hexokinase and glucose-6-phosphate dehydrogenase (p < 0.05) only. The experiments provided evidence to support the antihyperglycemic effect of guava leaf extract and the health function of guava leaves against type 2 diabetes.

Original languageEnglish
Pages (from-to)1458-1464
Number of pages7
JournalPhytotherapy Research
Volume22
Issue number11
DOIs
Publication statusPublished - 2008 Nov 1

Fingerprint

Psidium
Glucose
Hexokinase
Ethanol
Glucosephosphate Dehydrogenase
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Insulin
Phosphofructokinases
Niacinamide
Liver
Glucose Tolerance Test
Streptozocin
Hypoglycemia
Sprague Dawley Rats
Blood Glucose
Health

Keywords

  • Antihyperglycemia
  • Diabetes
  • Extract
  • Glucose metabolism
  • Guava

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effect of guava (psidium guajava linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats. / Shen, Szu-Chuan; Cheng, Fang Chi; Wu, Ning Jung.

In: Phytotherapy Research, Vol. 22, No. 11, 01.11.2008, p. 1458-1464.

Research output: Contribution to journalArticle

@article{6580224a073f445f8a70f7c5d440fb7b,
title = "Effect of guava (psidium guajava linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats",
abstract = "This study investigated the effect of aqueous and ethanol soluble solid extracts of guava (Psidium guajava Linn.) leaves on hypoglycemia and glucose metabolism in type 2 diabetic rats. Low-dose streptozotocin (STZ) and nicotinamide were injected into Sprague-Dawley (SD) rats to induce type 2 diabetes. Acute and long-term feeding tests were carried out, and an oral glucose tolerance test (OGTT) to follow the changes in plasma glucose and insulin levels was performed to evaluate the antihyperglycemic effect of guava leaf extracts in diabetic rats. The results of acute and long-term feeding tests showed a significant reduction in the blood sugar level in diabetic rats fed with either the aqueous or ethanol extract of guava leaves (p < 0.05). Long-term administration of guava leaf extracts increased the plasma insulin level and glucose utilization in diabetic rats. The results also indicated that the activities of hepatic hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase in diabetic rats fed with aqueous extracts were higher than in the normal diabetic group (p < 0.05). On the other hand, diabetic rats treated with the ethanol extract raised the activities of hepatic hexokinase and glucose-6-phosphate dehydrogenase (p < 0.05) only. The experiments provided evidence to support the antihyperglycemic effect of guava leaf extract and the health function of guava leaves against type 2 diabetes.",
keywords = "Antihyperglycemia, Diabetes, Extract, Glucose metabolism, Guava",
author = "Szu-Chuan Shen and Cheng, {Fang Chi} and Wu, {Ning Jung}",
year = "2008",
month = "11",
day = "1",
doi = "10.1002/ptr.2476",
language = "English",
volume = "22",
pages = "1458--1464",
journal = "Phytotherapy Research",
issn = "0951-418X",
publisher = "John Wiley and Sons Ltd",
number = "11",

}

TY - JOUR

T1 - Effect of guava (psidium guajava linn.) leaf soluble solids on glucose metabolism in type 2 diabetic rats

AU - Shen, Szu-Chuan

AU - Cheng, Fang Chi

AU - Wu, Ning Jung

PY - 2008/11/1

Y1 - 2008/11/1

N2 - This study investigated the effect of aqueous and ethanol soluble solid extracts of guava (Psidium guajava Linn.) leaves on hypoglycemia and glucose metabolism in type 2 diabetic rats. Low-dose streptozotocin (STZ) and nicotinamide were injected into Sprague-Dawley (SD) rats to induce type 2 diabetes. Acute and long-term feeding tests were carried out, and an oral glucose tolerance test (OGTT) to follow the changes in plasma glucose and insulin levels was performed to evaluate the antihyperglycemic effect of guava leaf extracts in diabetic rats. The results of acute and long-term feeding tests showed a significant reduction in the blood sugar level in diabetic rats fed with either the aqueous or ethanol extract of guava leaves (p < 0.05). Long-term administration of guava leaf extracts increased the plasma insulin level and glucose utilization in diabetic rats. The results also indicated that the activities of hepatic hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase in diabetic rats fed with aqueous extracts were higher than in the normal diabetic group (p < 0.05). On the other hand, diabetic rats treated with the ethanol extract raised the activities of hepatic hexokinase and glucose-6-phosphate dehydrogenase (p < 0.05) only. The experiments provided evidence to support the antihyperglycemic effect of guava leaf extract and the health function of guava leaves against type 2 diabetes.

AB - This study investigated the effect of aqueous and ethanol soluble solid extracts of guava (Psidium guajava Linn.) leaves on hypoglycemia and glucose metabolism in type 2 diabetic rats. Low-dose streptozotocin (STZ) and nicotinamide were injected into Sprague-Dawley (SD) rats to induce type 2 diabetes. Acute and long-term feeding tests were carried out, and an oral glucose tolerance test (OGTT) to follow the changes in plasma glucose and insulin levels was performed to evaluate the antihyperglycemic effect of guava leaf extracts in diabetic rats. The results of acute and long-term feeding tests showed a significant reduction in the blood sugar level in diabetic rats fed with either the aqueous or ethanol extract of guava leaves (p < 0.05). Long-term administration of guava leaf extracts increased the plasma insulin level and glucose utilization in diabetic rats. The results also indicated that the activities of hepatic hexokinase, phosphofructokinase and glucose-6-phosphate dehydrogenase in diabetic rats fed with aqueous extracts were higher than in the normal diabetic group (p < 0.05). On the other hand, diabetic rats treated with the ethanol extract raised the activities of hepatic hexokinase and glucose-6-phosphate dehydrogenase (p < 0.05) only. The experiments provided evidence to support the antihyperglycemic effect of guava leaf extract and the health function of guava leaves against type 2 diabetes.

KW - Antihyperglycemia

KW - Diabetes

KW - Extract

KW - Glucose metabolism

KW - Guava

UR - http://www.scopus.com/inward/record.url?scp=57349176526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=57349176526&partnerID=8YFLogxK

U2 - 10.1002/ptr.2476

DO - 10.1002/ptr.2476

M3 - Article

C2 - 18819164

AN - SCOPUS:57349176526

VL - 22

SP - 1458

EP - 1464

JO - Phytotherapy Research

JF - Phytotherapy Research

SN - 0951-418X

IS - 11

ER -