Effect of different gold nanoparticle sizes to build an electrical detection DNA between nanogap electrodes

Tien Li Chang; Ya Wei Lee; Chun Chi Chen; Fu Hsiang Ko

doi:10.1016/j.mee.2007.01.266

Effect of different gold nanoparticle sizes to build an electrical detection DNA between nanogap electrodes

Tien Li Chang^*, Ya Wei Lee, Chun Chi Chen, Fu Hsiang Ko

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

An experimental study for identifying DNA strands immobilized in the different particle sizes of gold nanoparticle (AuNP) between nanogap electrodes is presented. The nanogap-based electrics chip demonstrates a significant electrical property with a target DNA (TDNA) concentration of 10 pM in the different particle sizes of AuNP to be analyzed in order to make the assay useful for an integrated lab-on-a-chip application system. The biochips with nanogap electrodes are fabricated by e-beam lithography (EBL). Different from traditional detection methods including polymerase chain reaction (PCR) based on assays which are expensive and time consuming for DNA strands research. By the method of electrical characterization, a change in measured current through the different particle sizes of AuNP can pave the way for further use in sensitive biomolecule detection study.

Original language	English
Pages (from-to)	1698-1701
Number of pages	4
Journal	Microelectronic Engineering
Volume	84
Issue number	5-8
DOIs	https://doi.org/10.1016/j.mee.2007.01.266
Publication status	Published - 2007 May
Externally published	Yes

Keywords

DNA chip
Electrical detection
Gold Nanoparticles
Particle size
Self-assembly

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Atomic and Molecular Physics, and Optics
Condensed Matter Physics
Surfaces, Coatings and Films
Electrical and Electronic Engineering

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10.1016/j.mee.2007.01.266

Cite this

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title = "Effect of different gold nanoparticle sizes to build an electrical detection DNA between nanogap electrodes",

abstract = "An experimental study for identifying DNA strands immobilized in the different particle sizes of gold nanoparticle (AuNP) between nanogap electrodes is presented. The nanogap-based electrics chip demonstrates a significant electrical property with a target DNA (TDNA) concentration of 10 pM in the different particle sizes of AuNP to be analyzed in order to make the assay useful for an integrated lab-on-a-chip application system. The biochips with nanogap electrodes are fabricated by e-beam lithography (EBL). Different from traditional detection methods including polymerase chain reaction (PCR) based on assays which are expensive and time consuming for DNA strands research. By the method of electrical characterization, a change in measured current through the different particle sizes of AuNP can pave the way for further use in sensitive biomolecule detection study.",

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author = "Chang, {Tien Li} and Lee, {Ya Wei} and Chen, {Chun Chi} and Ko, {Fu Hsiang}",

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doi = "10.1016/j.mee.2007.01.266",

language = "English",

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journal = "Microelectronic Engineering",

issn = "0167-9317",

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number = "5-8",

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AU - Chang, Tien Li

AU - Lee, Ya Wei

AU - Chen, Chun Chi

AU - Ko, Fu Hsiang

PY - 2007/5

Y1 - 2007/5

N2 - An experimental study for identifying DNA strands immobilized in the different particle sizes of gold nanoparticle (AuNP) between nanogap electrodes is presented. The nanogap-based electrics chip demonstrates a significant electrical property with a target DNA (TDNA) concentration of 10 pM in the different particle sizes of AuNP to be analyzed in order to make the assay useful for an integrated lab-on-a-chip application system. The biochips with nanogap electrodes are fabricated by e-beam lithography (EBL). Different from traditional detection methods including polymerase chain reaction (PCR) based on assays which are expensive and time consuming for DNA strands research. By the method of electrical characterization, a change in measured current through the different particle sizes of AuNP can pave the way for further use in sensitive biomolecule detection study.

AB - An experimental study for identifying DNA strands immobilized in the different particle sizes of gold nanoparticle (AuNP) between nanogap electrodes is presented. The nanogap-based electrics chip demonstrates a significant electrical property with a target DNA (TDNA) concentration of 10 pM in the different particle sizes of AuNP to be analyzed in order to make the assay useful for an integrated lab-on-a-chip application system. The biochips with nanogap electrodes are fabricated by e-beam lithography (EBL). Different from traditional detection methods including polymerase chain reaction (PCR) based on assays which are expensive and time consuming for DNA strands research. By the method of electrical characterization, a change in measured current through the different particle sizes of AuNP can pave the way for further use in sensitive biomolecule detection study.

KW - DNA chip

KW - Electrical detection

KW - Gold Nanoparticles

KW - Particle size

KW - Self-assembly

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JO - Microelectronic Engineering

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IS - 5-8

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Effect of different gold nanoparticle sizes to build an electrical detection DNA between nanogap electrodes

Abstract

Keywords

ASJC Scopus subject areas

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