Effect of different gold nanoparticle sizes to build an electrical detection DNA between nanogap electrodes

Tien Li Chang, Ya Wei Lee, Chun Chi Chen, Fu Hsiang Ko

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

An experimental study for identifying DNA strands immobilized in the different particle sizes of gold nanoparticle (AuNP) between nanogap electrodes is presented. The nanogap-based electrics chip demonstrates a significant electrical property with a target DNA (TDNA) concentration of 10 pM in the different particle sizes of AuNP to be analyzed in order to make the assay useful for an integrated lab-on-a-chip application system. The biochips with nanogap electrodes are fabricated by e-beam lithography (EBL). Different from traditional detection methods including polymerase chain reaction (PCR) based on assays which are expensive and time consuming for DNA strands research. By the method of electrical characterization, a change in measured current through the different particle sizes of AuNP can pave the way for further use in sensitive biomolecule detection study.

Original languageEnglish
Pages (from-to)1698-1701
Number of pages4
JournalMicroelectronic Engineering
Volume84
Issue number5-8
DOIs
Publication statusPublished - 2007 May 1
Externally publishedYes

Keywords

  • DNA chip
  • Electrical detection
  • Gold Nanoparticles
  • Particle size
  • Self-assembly

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Condensed Matter Physics
  • Surfaces, Coatings and Films
  • Electrical and Electronic Engineering

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