Dual-Signal Microbial Biosensor for the Detection of Dopamine without Inference from Other Catecholamine Neurotransmitters

Yu Kuan Lin, Yi Chun Yeh

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Dopamine, one of catecholamine neurotransmitters, plays an important role in many brain functions and behavioral responses. In this study, we developed a novel dual-signal whole-cell biosensor for the detection of dopamine through the generation of red fluorescent proteins and 6-decarboxylated betaxanthin pigments. The proposed system responses specifically to dopamine with a detection limit of 1.43 μM. Furthermore, a combination of dual output signals makes it possible to reduce the interference from other catecholamine neurotransmitters, including L-DOPA, epinephrine, and norepinephrine.

Original languageEnglish
Pages (from-to)11178-11182
Number of pages5
JournalAnalytical Chemistry
Volume89
Issue number21
DOIs
Publication statusPublished - 2017 Nov 7

ASJC Scopus subject areas

  • Analytical Chemistry

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