Dual-Signal Microbial Biosensor for the Detection of Dopamine without Inference from Other Catecholamine Neurotransmitters

Yu Kuan Lin, Yi Chun Yeh

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Dopamine, one of catecholamine neurotransmitters, plays an important role in many brain functions and behavioral responses. In this study, we developed a novel dual-signal whole-cell biosensor for the detection of dopamine through the generation of red fluorescent proteins and 6-decarboxylated betaxanthin pigments. The proposed system responses specifically to dopamine with a detection limit of 1.43 μM. Furthermore, a combination of dual output signals makes it possible to reduce the interference from other catecholamine neurotransmitters, including L-DOPA, epinephrine, and norepinephrine.

Original languageEnglish
Pages (from-to)11178-11182
Number of pages5
JournalAnalytical Chemistry
Volume89
Issue number21
DOIs
Publication statusPublished - 2017 Nov 7

Fingerprint

Biosensing Techniques
Biosensors
Catecholamines
Neurotransmitter Agents
Dopamine
Pigments
Epinephrine
Limit of Detection
Brain
Norepinephrine

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Dual-Signal Microbial Biosensor for the Detection of Dopamine without Inference from Other Catecholamine Neurotransmitters. / Lin, Yu Kuan; Yeh, Yi Chun.

In: Analytical Chemistry, Vol. 89, No. 21, 07.11.2017, p. 11178-11182.

Research output: Contribution to journalArticle

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