Dual immobilization and magnetic manipulation of magnetic nanoparticles

S. Y. Yang; Z. F. Jian; H. E. Horng; Chin Yih Hong; H. C. Yang; C. C. Wu; Y. H. Lee

doi:10.1016/j.jmmm.2008.05.048

Dual immobilization and magnetic manipulation of magnetic nanoparticles

S. Y. Yang, Z. F. Jian, H. E. Horng, Chin Yih Hong, H. C. Yang, C. C. Wu, Y. H. Lee

Undergraduate Program of Electro-Optical Engineering

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

Original language	English
Pages (from-to)	2688-2691
Number of pages	4
Journal	Journal of Magnetism and Magnetic Materials
Volume	320
Issue number	21
DOIs	https://doi.org/10.1016/j.jmmm.2008.05.048
Publication status	Published - 2008 Nov

Keywords

Bio-vector
Magnetic nanoparticles
Stem cell

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics

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10.1016/j.jmmm.2008.05.048

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title = "Dual immobilization and magnetic manipulation of magnetic nanoparticles",

abstract = "By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.",

keywords = "Bio-vector, Magnetic nanoparticles, Stem cell",

author = "Yang, {S. Y.} and Jian, {Z. F.} and Horng, {H. E.} and Hong, {Chin Yih} and Yang, {H. C.} and Wu, {C. C.} and Lee, {Y. H.}",

note = "Funding Information: This work is supported by National Science Council, Taiwan under Grant nos., NSC95-2120-M-003-001, 96-2314-B-002-150-MY3, 96-2628-M-003-002, 95-2112-M-003-017-MY2, and 96-2752-M002-016-PAE.",

year = "2008",

month = nov,

doi = "10.1016/j.jmmm.2008.05.048",

language = "English",

volume = "320",

pages = "2688--2691",

journal = "Journal of Magnetism and Magnetic Materials",

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T1 - Dual immobilization and magnetic manipulation of magnetic nanoparticles

AU - Yang, S. Y.

AU - Jian, Z. F.

AU - Horng, H. E.

AU - Hong, Chin Yih

AU - Yang, H. C.

AU - Wu, C. C.

AU - Lee, Y. H.

N1 - Funding Information: This work is supported by National Science Council, Taiwan under Grant nos., NSC95-2120-M-003-001, 96-2314-B-002-150-MY3, 96-2628-M-003-002, 95-2112-M-003-017-MY2, and 96-2752-M002-016-PAE.

PY - 2008/11

Y1 - 2008/11

N2 - By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

AB - By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

KW - Bio-vector

KW - Magnetic nanoparticles

KW - Stem cell

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JO - Journal of Magnetism and Magnetic Materials

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Dual immobilization and magnetic manipulation of magnetic nanoparticles

Abstract

Keywords

ASJC Scopus subject areas

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