Dual immobilization and magnetic manipulation of magnetic nanoparticles

Shieh-Yueh Yang, Z. F. Jian, Herng-Er Horng, Chin Yih Hong, Hong-Chang Yang, C. C. Wu, Y. H. Lee

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

Original languageEnglish
Pages (from-to)2688-2691
Number of pages4
JournalJournal of Magnetism and Magnetic Materials
Volume320
Issue number21
DOIs
Publication statusPublished - 2008 Jan 1

Fingerprint

immobilization
manipulators
Nanoparticles
nanoparticles
myocardium
stem cells
Biomolecules
Stem cells
creatine
MB Form Creatine Kinase
Troponin I
probes
Tissue
Magnetic fields
coatings
Coatings
synthesis
magnetic fields

Keywords

  • Bio-vector
  • Magnetic nanoparticles
  • Stem cell

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Cite this

Dual immobilization and magnetic manipulation of magnetic nanoparticles. / Yang, Shieh-Yueh; Jian, Z. F.; Horng, Herng-Er; Hong, Chin Yih; Yang, Hong-Chang; Wu, C. C.; Lee, Y. H.

In: Journal of Magnetism and Magnetic Materials, Vol. 320, No. 21, 01.01.2008, p. 2688-2691.

Research output: Contribution to journalArticle

Yang, Shieh-Yueh ; Jian, Z. F. ; Horng, Herng-Er ; Hong, Chin Yih ; Yang, Hong-Chang ; Wu, C. C. ; Lee, Y. H. / Dual immobilization and magnetic manipulation of magnetic nanoparticles. In: Journal of Magnetism and Magnetic Materials. 2008 ; Vol. 320, No. 21. pp. 2688-2691.
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