Dual immobilization and magnetic manipulation of magnetic nanoparticles

Shieh-Yueh Yang, Z. F. Jian, Herng-Er Horng, Chin Yih Hong, Hong-Chang Yang, C. C. Wu, Y. H. Lee

    Research output: Contribution to journalArticlepeer-review

    28 Citations (Scopus)

    Abstract

    By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

    Original languageEnglish
    Pages (from-to)2688-2691
    Number of pages4
    JournalJournal of Magnetism and Magnetic Materials
    Volume320
    Issue number21
    DOIs
    Publication statusPublished - 2008 Jan 1

    Keywords

    • Bio-vector
    • Magnetic nanoparticles
    • Stem cell

    ASJC Scopus subject areas

    • Electronic, Optical and Magnetic Materials
    • Condensed Matter Physics

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