Dual immobilization and magnetic manipulation of magnetic nanoparticles

S. Y. Yang, Z. F. Jian, H. E. Horng, Chin Yih Hong, H. C. Yang, C. C. Wu, Y. H. Lee

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

By suitably bio-functionalizing the surfaces, magnetic nanoparticles are able to bind specific biomolecules, and may serve as vectors for delivering bio-entities to target tissues. In this work, the synthesis of bio-functionalized magnetic nanoparticles with two kinds of bio-probes is developed. Here, the stem cell is selected as a to-be-delivered bio-entity and infarcted myocardium is the target issue. Thus, cluster designation-34 (CD-34) on stem cell and creatine kinase-MB (CK-MB) (or troponin I) on infarcted myocardium are the specific biomolecules to be bound with bio-functionalized magnetic nanoparticles. In addition to demonstrating the co-coating of two kinds of bio-probes on a magnetic nanoparticle, the feasibility of manipulation on bio-functionalized magnetic nanoparticles by external magnetic fields is investigated.

Original languageEnglish
Pages (from-to)2688-2691
Number of pages4
JournalJournal of Magnetism and Magnetic Materials
Volume320
Issue number21
DOIs
Publication statusPublished - 2008 Nov

Keywords

  • Bio-vector
  • Magnetic nanoparticles
  • Stem cell

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics

Fingerprint Dive into the research topics of 'Dual immobilization and magnetic manipulation of magnetic nanoparticles'. Together they form a unique fingerprint.

Cite this