Driven translocation dynamics of polynucleotides through a nanopore

Off-lattice Monte-Carlo simulations

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The driven translocation dynamics of a polynucleotide chain through a nanopore is studied using off-lattice Monte-Carlo simulations, which plays an important role in the nanopore sequencing of polynucleotides. We report a detailed study on the dependence of translocation dynamics on the chain length and the local geometry near the nanopore. In particular, we find that the length dependence of the infection time of the chain could exhibit very different behaviors for different geometries.

Original languageEnglish
Pages (from-to)95-107
Number of pages13
JournalPhysica A: Statistical Mechanics and its Applications
Volume350
Issue number1
DOIs
Publication statusPublished - 2005 May 1

Fingerprint

polynucleotides
Nanopore
Translocation
Monte Carlo Simulation
sequencing
simulation
infectious diseases
geometry
Sequencing
Infection

ASJC Scopus subject areas

  • Mathematical Physics
  • Statistical and Nonlinear Physics

Cite this

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abstract = "The driven translocation dynamics of a polynucleotide chain through a nanopore is studied using off-lattice Monte-Carlo simulations, which plays an important role in the nanopore sequencing of polynucleotides. We report a detailed study on the dependence of translocation dynamics on the chain length and the local geometry near the nanopore. In particular, we find that the length dependence of the infection time of the chain could exhibit very different behaviors for different geometries.",
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