TY - JOUR
T1 - Doubly end-on azido bridged mixed-valence cobalt trinuclear complex
T2 - Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells
AU - Datta, Amitabha
AU - Das, Kuheli
AU - Sen, Chandana
AU - Karan, Nirmal Kumar
AU - Huang, Jui Hsien
AU - Lin, Chia Her
AU - Garribba, Eugenio
AU - Sinha, Chittaranjan
AU - Askun, Tulin
AU - Celikboyun, Pinar
AU - Mane, Sandeep B.
N1 - Funding Information:
Amitabha Datta would like to thank the Scientific & Technological Research Council of Turkey (TÜBITAK) for the grant (2221 – Fellowship for Visiting Scientist). Kuheli Das and Chittaranjan Sinha would like to thank DST (Department of Science and Technology, New Delhi, India) for the grant (SR/S1/IC-31/2008). Jui-Hsien Huang thanks the National Changhua University of Education for providing the X-ray diffractometer facility.
Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/9/5
Y1 - 2015/9/5
N2 - Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[[2-(dimethylamino)ethyl]imino}ethyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent CoII and CoIII ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15 K and then reaches to the value 1.56 cm3 K mol-1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.
AB - Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[[2-(dimethylamino)ethyl]imino}ethyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent CoII and CoIII ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15 K and then reaches to the value 1.56 cm3 K mol-1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.
KW - Anti-mycobacterial activity
KW - Co complex
KW - Crystal structure
KW - EPR
KW - Inhibitory effect
KW - VTM
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U2 - 10.1016/j.saa.2015.04.014
DO - 10.1016/j.saa.2015.04.014
M3 - Article
C2 - 25932976
AN - SCOPUS:84928549921
SN - 1386-1425
VL - 148
SP - 427
EP - 434
JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
ER -
