Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells

Amitabha Datta; Kuheli Das; Chandana Sen; Nirmal Kumar Karan; Jui Hsien Huang; Chia Her Lin; Eugenio Garribba; Chittaranjan Sinha; Tulin Askun; Pinar Celikboyun; Sandeep B. Mane

doi:10.1016/j.saa.2015.04.014

Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells

Amitabha Datta^*, Kuheli Das, Chandana Sen, Nirmal Kumar Karan, Jui Hsien Huang, Chia Her Lin, Eugenio Garribba, Chittaranjan Sinha, Tulin Askun, Pinar Celikboyun, Sandeep B. Mane

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co₃(L)₂(N₃)₆(CH₃OH)₂] (1) is afforded by employing a potential monoanionic tetradentate-N₂O₂ Schiff base precursor (2-[[2-(dimethylamino)ethyl]imino}ethyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent Co^II and Co^III ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χ_MT values decrease smoothly until 15 K and then reaches to the value 1.56 cm³ K mol^-1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.

Original language	English
Pages (from-to)	427-434
Number of pages	8
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	148
DOIs	https://doi.org/10.1016/j.saa.2015.04.014
Publication status	Published - 2015 Sept 5
Externally published	Yes

Keywords

Anti-mycobacterial activity
Co complex
Crystal structure
EPR
Inhibitory effect
VTM

ASJC Scopus subject areas

Analytical Chemistry
Atomic and Molecular Physics, and Optics
Instrumentation
Spectroscopy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.saa.2015.04.014

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Datta, A., Das, K., Sen, C., Karan, N. K., Huang, J. H., Lin, C. H., Garribba, E., Sinha, C., Askun, T., Celikboyun, P., & Mane, S. B. (2015). Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells. Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 148, 427-434. https://doi.org/10.1016/j.saa.2015.04.014

Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells. / Datta, Amitabha; Das, Kuheli; Sen, Chandana et al.
In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Vol. 148, 05.09.2015, p. 427-434.

Research output: Contribution to journal › Article › peer-review

Datta, A, Das, K, Sen, C, Karan, NK, Huang, JH, Lin, CH, Garribba, E, Sinha, C, Askun, T, Celikboyun, P & Mane, SB 2015, 'Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells', Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, vol. 148, pp. 427-434. https://doi.org/10.1016/j.saa.2015.04.014

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abstract = "Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[[2-(dimethylamino)ethyl]imino}ethyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent CoII and CoIII ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15 K and then reaches to the value 1.56 cm3 K mol-1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.",

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author = "Amitabha Datta and Kuheli Das and Chandana Sen and Karan, {Nirmal Kumar} and Huang, {Jui Hsien} and Lin, {Chia Her} and Eugenio Garribba and Chittaranjan Sinha and Tulin Askun and Pinar Celikboyun and Mane, {Sandeep B.}",

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doi = "10.1016/j.saa.2015.04.014",

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T2 - Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells

AU - Datta, Amitabha

AU - Das, Kuheli

AU - Sen, Chandana

AU - Karan, Nirmal Kumar

AU - Huang, Jui Hsien

AU - Lin, Chia Her

AU - Garribba, Eugenio

AU - Sinha, Chittaranjan

AU - Askun, Tulin

AU - Celikboyun, Pinar

AU - Mane, Sandeep B.

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AB - Doubly end-on azido-bridged mixed-valence trinuclear cobalt complex, [Co3(L)2(N3)6(CH3OH)2] (1) is afforded by employing a potential monoanionic tetradentate-N2O2 Schiff base precursor (2-[[2-(dimethylamino)ethyl]imino}ethyl]-6-methoxyphenol; HL). Single crystal X-ray structure reveals that in 1, the adjacent CoII and CoIII ions are linked by double end-on azido bridges and thus the full molecule is generated by the site symmetry of a crystallographic twofold rotation axis. Complex 1 is subjected on different spectral analysis such as IR, UV-vis, emission and EPR spectroscopy. On variable temperature magnetic study, we observe that during cooling, the χMT values decrease smoothly until 15 K and then reaches to the value 1.56 cm3 K mol-1 at 2 K. Complex 1 inhibits the cell growth on human lung carcinoma (A549 cells), human colorectal (COLO 205 and HT-29 cells), and human heptacellular (PLC5 cells) carcinoma cells. Complex 1 exhibits anti-mycobacterial activity and considerable efficacy on Mycobacterium tuberculosis H37Rv ATCC 27294 and H37Ra ATCC 25177 strains.

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KW - Inhibitory effect

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Doubly end-on azido bridged mixed-valence cobalt trinuclear complex: Spectral study, VTM, inhibitory effect and antimycobacterial activity on human carcinoma and tuberculosis cells

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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