Do calcium buffers always slow down the propagation of calcium waves?

Research output: Contribution to journalArticle

Abstract

Calcium buffers are large proteins that act as binding sites for free cytosolic calcium. Since a large fraction of cytosolic calcium is bound to calcium buffers, calcium waves are widely observed under the condition that free cytosolic calcium is heavily buffered. In addition, all physiological buffered excitable systems contain multiple buffers with different affinities. It is thus important to understand the properties of waves in excitable systems with the inclusion of buffers. There is an ongoing controversy about whether or not the addition of calcium buffers into the system always slows down the propagation of calcium waves. To solve this controversy, we incorporate the buffering effect into the generic excitable system, the FitzHugh-Nagumo model, to get the buffered FitzHugh-Nagumo model, and then to study the effect of the added buffer with large diffusivity on traveling waves of such a model in one spatial dimension. We can find a critical dissociation constant (K = K(a)) characterized by system excitability parameter a such that calcium buffers can be classified into two types: weak buffers (K ∈ K(a), ∞) and strong buffers (K ∈ (0, K(a)). We analytically show that the addition of weak buffers or strong buffers but with its total concentration b01. below some critical total concentration b01,c into the system can generate a traveling wave of the resulting system which propagates faster than that of the origin system, provided that the diffusivity D1 of the added buffers is sufficiently large. Further, the magnitude of the wave speed of traveling waves of the resulting system is proportional to √D1 as D1 → ∞. In contrast, the addition of strong buffers with the total concentration b01>b01,c into the system may not be able to support the formation of a biologically acceptable wave provided that the diffusivity D1 of the added buffers is sufficiently large.

Original languageEnglish
Pages (from-to)1587-1632
Number of pages46
JournalJournal of Mathematical Biology
Volume67
Issue number6-7
DOIs
Publication statusPublished - 2013 Dec 1

Fingerprint

Calcium Signaling
Calcium
Buffer
Buffers
buffers
Propagation
calcium
Excitable Systems
Diffusivity
diffusivity
Traveling Wave
FitzHugh-Nagumo
Binding sites
Excitability
Wave Speed
Proteins
Affine transformation
binding sites

Keywords

  • Buffer
  • Buffered FitzHugh-Nagumo model
  • Calcium
  • Traveling wave

ASJC Scopus subject areas

  • Modelling and Simulation
  • Agricultural and Biological Sciences (miscellaneous)
  • Applied Mathematics

Cite this

Do calcium buffers always slow down the propagation of calcium waves? / Tsai, Je-Chiang.

In: Journal of Mathematical Biology, Vol. 67, No. 6-7, 01.12.2013, p. 1587-1632.

Research output: Contribution to journalArticle

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