DNA binding and cleavage activity of a structurally characterized Ni(II) Schiff base complex

Sarat Chandra Kumar; Abhijit Pal; Merry Mitra; V. M. Manikandamathavan; Chia Her Lin; Balachandran Unni Nair; Rajarshi Ghosh

doi:10.1007/s12039-015-0900-4

DNA binding and cleavage activity of a structurally characterized Ni(II) Schiff base complex

Sarat Chandra Kumar
, Abhijit Pal
, Merry Mitra
, V. M. Manikandamathavan
, Chia Her Lin
, Balachandran Unni Nair^*
, Rajarshi Ghosh

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Synthesis and characterization of a mononuclear Ni(II) compound [Ni(L)(H₂O)₂](NO₃)₂ [L = N,N'-bis((pyridine-2-yl)phenylidene)-1,3-diaminopropan-2-ol] (1) is reported. 1 crystallizes in triclinic P-1 space group with a = 8.1911(2) Å, b = 11.6624(3) Å, c = 16.5356(4) Å and α = 108.8120(10)°, β = 91.2010(10)°, γ = 91.1500(10)°. The binding property of the complex with DNA has been investigated using absorption and emission studies, and viscosity experiment. The binding constant (K_b) and the linear Stern-Volmer quenching constant (K_sv) of the complex have been determined as 9.23 × 10⁴ M^-1 and 2.0 × 10⁴ M^-1, respectively. Spectroscopic and hydrodynamic investigations revealed groove or electrostatic nature of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner. [Figure not available: see fulltext.]

Original language	English
Pages (from-to)	1375-1381
Number of pages	7
Journal	Journal of Chemical Sciences
Volume	127
Issue number	8
DOIs	https://doi.org/10.1007/s12039-015-0900-4
Publication status	Published - 2015 Aug 1
Externally published	Yes

Keywords

DNA cleavage
Nickel(II)
Schiff base
crystal structure

ASJC Scopus subject areas

General Chemistry

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10.1007/s12039-015-0900-4

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@article{e7d8bd8574c64a6e9a5debb11d5deeb4,

title = "DNA binding and cleavage activity of a structurally characterized Ni(II) Schiff base complex",

abstract = "Synthesis and characterization of a mononuclear Ni(II) compound [Ni(L)(H2O)2](NO3)2 [L = N,N'-bis((pyridine-2-yl)phenylidene)-1,3-diaminopropan-2-ol] (1) is reported. 1 crystallizes in triclinic P-1 space group with a = 8.1911(2) {\AA}, b = 11.6624(3) {\AA}, c = 16.5356(4) {\AA} and α = 108.8120(10)°, β = 91.2010(10)°, γ = 91.1500(10)°. The binding property of the complex with DNA has been investigated using absorption and emission studies, and viscosity experiment. The binding constant (Kb) and the linear Stern-Volmer quenching constant (Ksv) of the complex have been determined as 9.23 × 104 M-1 and 2.0 × 104 M-1, respectively. Spectroscopic and hydrodynamic investigations revealed groove or electrostatic nature of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner. [Figure not available: see fulltext.]",

keywords = "DNA cleavage, Nickel(II), Schiff base, crystal structure",

author = "Kumar, \{Sarat Chandra\} and Abhijit Pal and Merry Mitra and Manikandamathavan, \{V. M.\} and Lin, \{Chia Her\} and Nair, \{Balachandran Unni\} and Rajarshi Ghosh",

note = "Publisher Copyright: {\textcopyright} 2015 Indian Academy of Sciences.",

year = "2015",

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doi = "10.1007/s12039-015-0900-4",

language = "English",

volume = "127",

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TY - JOUR

T1 - DNA binding and cleavage activity of a structurally characterized Ni(II) Schiff base complex

AU - Kumar, Sarat Chandra

AU - Pal, Abhijit

AU - Mitra, Merry

AU - Manikandamathavan, V. M.

AU - Lin, Chia Her

AU - Nair, Balachandran Unni

AU - Ghosh, Rajarshi

PY - 2015/8/1

Y1 - 2015/8/1

N2 - Synthesis and characterization of a mononuclear Ni(II) compound [Ni(L)(H2O)2](NO3)2 [L = N,N'-bis((pyridine-2-yl)phenylidene)-1,3-diaminopropan-2-ol] (1) is reported. 1 crystallizes in triclinic P-1 space group with a = 8.1911(2) Å, b = 11.6624(3) Å, c = 16.5356(4) Å and α = 108.8120(10)°, β = 91.2010(10)°, γ = 91.1500(10)°. The binding property of the complex with DNA has been investigated using absorption and emission studies, and viscosity experiment. The binding constant (Kb) and the linear Stern-Volmer quenching constant (Ksv) of the complex have been determined as 9.23 × 104 M-1 and 2.0 × 104 M-1, respectively. Spectroscopic and hydrodynamic investigations revealed groove or electrostatic nature of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner. [Figure not available: see fulltext.]

AB - Synthesis and characterization of a mononuclear Ni(II) compound [Ni(L)(H2O)2](NO3)2 [L = N,N'-bis((pyridine-2-yl)phenylidene)-1,3-diaminopropan-2-ol] (1) is reported. 1 crystallizes in triclinic P-1 space group with a = 8.1911(2) Å, b = 11.6624(3) Å, c = 16.5356(4) Å and α = 108.8120(10)°, β = 91.2010(10)°, γ = 91.1500(10)°. The binding property of the complex with DNA has been investigated using absorption and emission studies, and viscosity experiment. The binding constant (Kb) and the linear Stern-Volmer quenching constant (Ksv) of the complex have been determined as 9.23 × 104 M-1 and 2.0 × 104 M-1, respectively. Spectroscopic and hydrodynamic investigations revealed groove or electrostatic nature of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner. [Figure not available: see fulltext.]

KW - DNA cleavage

KW - Nickel(II)

KW - Schiff base

KW - crystal structure

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DO - 10.1007/s12039-015-0900-4

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SN - 0974-3626

VL - 127

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JO - Journal of Chemical Sciences

JF - Journal of Chemical Sciences

IS - 8

ER -

DNA binding and cleavage activity of a structurally characterized Ni(II) Schiff base complex

Abstract

Keywords

ASJC Scopus subject areas

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