TY - JOUR
T1 - DNA binding and cleavage activity of a structurally characterized Ni(II) Schiff base complex
AU - Kumar, Sarat Chandra
AU - Pal, Abhijit
AU - Mitra, Merry
AU - Manikandamathavan, V. M.
AU - Lin, Chia Her
AU - Nair, Balachandran Unni
AU - Ghosh, Rajarshi
N1 - Publisher Copyright:
© 2015 Indian Academy of Sciences.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Synthesis and characterization of a mononuclear Ni(II) compound [Ni(L)(H2O)2](NO3)2 [L = N,N'-bis((pyridine-2-yl)phenylidene)-1,3-diaminopropan-2-ol] (1) is reported. 1 crystallizes in triclinic P-1 space group with a = 8.1911(2) Å, b = 11.6624(3) Å, c = 16.5356(4) Å and α = 108.8120(10)°, β = 91.2010(10)°, γ = 91.1500(10)°. The binding property of the complex with DNA has been investigated using absorption and emission studies, and viscosity experiment. The binding constant (Kb) and the linear Stern-Volmer quenching constant (Ksv) of the complex have been determined as 9.23 × 104 M-1 and 2.0 × 104 M-1, respectively. Spectroscopic and hydrodynamic investigations revealed groove or electrostatic nature of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner. [Figure not available: see fulltext.]
AB - Synthesis and characterization of a mononuclear Ni(II) compound [Ni(L)(H2O)2](NO3)2 [L = N,N'-bis((pyridine-2-yl)phenylidene)-1,3-diaminopropan-2-ol] (1) is reported. 1 crystallizes in triclinic P-1 space group with a = 8.1911(2) Å, b = 11.6624(3) Å, c = 16.5356(4) Å and α = 108.8120(10)°, β = 91.2010(10)°, γ = 91.1500(10)°. The binding property of the complex with DNA has been investigated using absorption and emission studies, and viscosity experiment. The binding constant (Kb) and the linear Stern-Volmer quenching constant (Ksv) of the complex have been determined as 9.23 × 104 M-1 and 2.0 × 104 M-1, respectively. Spectroscopic and hydrodynamic investigations revealed groove or electrostatic nature of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner. [Figure not available: see fulltext.]
KW - DNA cleavage
KW - Nickel(II)
KW - Schiff base
KW - crystal structure
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U2 - 10.1007/s12039-015-0900-4
DO - 10.1007/s12039-015-0900-4
M3 - Article
AN - SCOPUS:84945258381
SN - 0974-3626
VL - 127
SP - 1375
EP - 1381
JO - Journal of Chemical Sciences
JF - Journal of Chemical Sciences
IS - 8
ER -