DNA binding and cleavage activity of a structurally characterized Ni(II) Schiff base complex

Sarat Chandra Kumar, Abhijit Pal, Merry Mitra, V. M. Manikandamathavan, Chia Her Lin, Balachandran Unni Nair*, Rajarshi Ghosh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Synthesis and characterization of a mononuclear Ni(II) compound [Ni(L)(H2O)2](NO3)2 [L = N,N'-bis((pyridine-2-yl)phenylidene)-1,3-diaminopropan-2-ol] (1) is reported. 1 crystallizes in triclinic P-1 space group with a = 8.1911(2) Å, b = 11.6624(3) Å, c = 16.5356(4) Å and α = 108.8120(10)°, β = 91.2010(10)°, γ = 91.1500(10)°. The binding property of the complex with DNA has been investigated using absorption and emission studies, and viscosity experiment. The binding constant (Kb) and the linear Stern-Volmer quenching constant (Ksv) of the complex have been determined as 9.23 × 104 M-1 and 2.0 × 104 M-1, respectively. Spectroscopic and hydrodynamic investigations revealed groove or electrostatic nature of binding of 1 with DNA. 1 is also found to induce oxidative cleavage of the supercoiled pUC 18 DNA to its nicked circular form in a concentration dependent manner. [Figure not available: see fulltext.]

Original languageEnglish
Pages (from-to)1375-1381
Number of pages7
JournalJournal of Chemical Sciences
Volume127
Issue number8
DOIs
Publication statusPublished - 2015 Aug 1
Externally publishedYes

Keywords

  • crystal structure
  • DNA cleavage
  • Nickel(II)
  • Schiff base

ASJC Scopus subject areas

  • Chemistry(all)

Fingerprint

Dive into the research topics of 'DNA binding and cleavage activity of a structurally characterized Ni(II) Schiff base complex'. Together they form a unique fingerprint.

Cite this